AI Article Synopsis
- DBU effectively catalyzes the amidation of acyl imidazoles, enhancing the reaction rates, especially with less reactive, electron-deficient anilines.
- It is more accessible and safer, presenting cost benefits compared to traditional catalysts like 1-hydroxybenzotriazole.
- This makes DBU a valuable alternative for organic synthesis in the lab.
Article Abstract
1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) has been found to catalyze the amidation of acyl imidazoles. The rate acceleration is especially evident with traditionally unreactive, electron-deficient anilines. DBU is readily available and offers safety and cost advantages over more commonly employed catalysts such as 1-hydroxybenzotriazole.
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| http://dx.doi.org/10.1021/ol9026599 | DOI Listing |
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