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Enhanced Sonodynamic Therapy for Deep Tumors Using a Self-Assembled Organoplatinum(II) Sonosensitizer.
J Med Chem
October 2024
School of Pharmaceutical Science, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, China.
Article Synopsis
- Advances in photodynamic therapy (PDT) face challenges in effectively targeting deep-seated solid tumors, prompting the development of a new organoplatinum(II) complex for sonodynamic therapy (SDT).
- This complex forms a nanofiber network that enhances singlet oxygen generation when activated by ultrasound, specifically in its self-assembled state.
- The treatment shows significant effectiveness against cancer cells and deep tumors in mice, demonstrating its potential to improve SDT outcomes.
Synthesis and crystal structures of three organoplatinum(II) complexes bearing natural aryl-olefin and quinoline derivatives.
Acta Crystallogr E Crystallogr Commun
May 2024
Department of Chemistry, KU Leuven, Biomolecular Architecture, Celestijnenlaan 200F, Leuven (Heverlee), B-3001, Belgium.
Three organoplatinum(II) complexes bearing natural aryl-olefin and quinoline derivatives, namely, [4-meth-oxy-5-(2-meth-oxy-2-oxoeth-oxy)-2-(prop-2-en-1-yl)phen-yl](quinolin-8-olato)platinum(II), [Pt(CHO)(CHNO)], (), [4-meth-oxy-5-(2-oxo-2-propoxyeth-oxy)-2-(prop-2-en-1-yl)phen-yl](quinoline-2-carboxy-l-ato)platinum(II), [Pt(CHO)(CHNO)], (), and chlorido-[4-meth-oxy-5-(2-oxo-2-propoxyeth-oxy)-2-(prop-2-en-1-yl)phen-yl](quinoline)-plat-inum(II), [Pt(CHO)Cl(CHN)], (), were synthesized and structurally characterized by IR and H NMR spectroscopy, and by single-crystal X-ray diffraction. The results showed that the cyclo-platinated aryl-olefin coordinates with Pt the carbon atom of the phenyl ring and the C=C group. The deprotonated 8-hy-droxy-quinoline (CHNO) and quinoline-2-carb-oxy-lic acid (CHNO) coordinate with the Pt atom the N and O atoms in complexes () and () while the quinoline (CHN) coordinates the N atom in ().
View Article and Find Full Text PDFFacile Access to Cationic Methylstannylenes and Silylenes Stabilized by E-Pt Bonding and their Methyl Group Transfer Reactivity.
Chemistry
February 2024
Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa, 904-0495, Japan.
We describe a family of cationic methylstannylene and chloro- and azidosilylene organoplatinum(II) complexes supported by a neutral, binucleating ligand. Methylstannylenes MeSn: are stabilized by coordination to Pt and are formed by facile Me group transfer from dimethyl or monomethyl Pt complexes, in the latter case triggered by concomitant B-H, Si-H, and H bond activation that involves hydride transfer from Sn to Pt. A cationic chlorosilylene complex was obtained by formal HCl elimination and Cl removal from HSiCl under ambient conditions.
View Article and Find Full Text PDFSupramolecular Assembly of Organoplatinum(II) Complexes for Subcellular Distribution and Cell Viability Monitoring with Differentiated Imaging.
Angew Chem Int Ed Engl
December 2022
Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
The ability to precisely control the subcellular distribution of luminous materials presents unprecedented advantages for understanding cell biology and disease therapy. We introduce a luminescence tool for subcellular distribution imaging and differentiation of live and dead cells, utilizing cationic organoplatinum(II) complexes that exhibit well-defined monomeric to aggregate nanostructures along with concentration-dependent switchable luminescence from green to red due to assembly via Pt ⋅⋅⋅Pt and π-π stacking interactions. One of the complexes was chosen to demonstrate the unique lysosome-to-nucleus subcellular re-distribution and imaging capability in live and dead cells, respectively, which represents the first example to discriminate the subcellular localization of platinum(II) complexes through differential luminescence response.
View Article and Find Full Text PDFHigh-Strength Plus Reversible Supramolecular Adhesives Achieved by Regulating Intermolecular Pt ⋅⋅⋅Pt Interactions.
Angew Chem Int Ed Engl
October 2022
CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, CAS Center for Excellence in Nanoscience, Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Surface adhesion has a great contradiction in high strength and good reversibility given their mutually exclusive requirements of fixed crosslinked networks and dynamic chain motion. Herein, we demonstrate a supramolecular organoplatinum(II) adhesive system regulated by intermolecular Pt ⋅⋅⋅Pt interactions that can simultaneously achieve high-strength and excellent reversible adhesion to various substrates. Upon alternating temperature, the assembly of suitably substituted organoplatinum(II) molecules can switch between well-ordered and disordered states via tuning Pt ⋅⋅⋅Pt interactions, resulting in stable reversible adhesion even after 100 cycles with a robust strength of ≈1.
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