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EFFECT OF DECEPTIVE VERSUS NON-DECEPTIVE PLACEBO ON PSYCHOMOTOR AND COGNITIVE FUNCTIONS IN HEALTHY ADULT HUMAN VOLUNTEERS: AN OPEN-LABEL CROSS-OVER RANDOMIZED CONTROLLED TRIAL.
Psychiatr Danub
December 2024
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
This study was planned to evaluate the effect of a placebo administered with deception vs. without deception on psychomotor and cognitive functions in healthy human volunteers compared to no treatment as placebo responses tend to be circumstantial. An open-label, 3-period, 6-sequence randomized controlled cross-over trial was conducted with 54 participants in a tertiary care center.
View Article and Find Full Text PDFEffects of an open-label placebo on visual attention directed to food high in sugar, appetite, and desire for sweet taste.
Appetite
February 2025
Institute of Psychology, University of Graz, Graz, Austria.
Background: Interventions with deceptive placebos can reduce visual attention directed to high-calorie sweets. Open-label placebos (OLPs), which avoid the ethical concerns associated with deception, have shown promise in various fields. This is the first study to test the effects of OLPs on appetite, desire for sweet taste and visual attention for high-sugar foods.
View Article and Find Full Text PDFDoes ischemic preconditioning enhance sports performance more than placebo or no intervention? A systematic review with meta-analysis.
J Sport Health Sci
November 2024
Department of Biophysics and Physiology, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil; Postgraduate Program in Physical Education, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil; Department of Training and Exercise Science, Faculty of Sport Science, Ruhr University Bochum, Bochum, Germany.
Background: Ischemic preconditioning (IPC) is purported to have beneficial effects on athletic performance, although findings are inconsistent, with some studies reporting placebo effects. The majority of studies have investigated IPC alongside a placebo condition, but without a control condition that was devoid of experimental manipulation, thereby limiting accurate determination of the IPC effects. Therefore, the aims of this study wereto assess the impact of the IPC intervention, compared to both placebo and no intervention, on exercise capacity and athletic performance.
View Article and Find Full Text PDF"I am open to self-belief": A study examining the impact of open-label effects on postexercise affect and postintervention exercise behaviour.
J Sports Sci
December 2024
School of Psychology, Beijing Sport University, Beijing, PR China.
The contribution of placebo effects can be measured by manipulating psychological factors, such as positive expectations for exercise outcomes, without the need for traditional placebos (such as inert substances). While placebo effects are well known, research has revealed intriguing findings suggesting that placebos can have beneficial effects even when studies are performed without deception. Open-label placebo (OLP) interventions (prescribed honestly), which harness the power of belief, may represent another effective method for enhancing the benefits of exercise effects.
View Article and Find Full Text PDFThe Ethics of Placebo.
Anesthesiol Clin
December 2024
Pacific Parkinson's Research Centre and Djavad Mowafaghian Centre for Brain Health and Division of Neurology, University of British Columbia, Vancouver, British Columbia V6T1Z3, Canada. Electronic address:
This article reviews the ethical implications related to the use of placebos in clinical practice and clinical trials. We discuss evidence for placebo effects, the role of placebo in research and clinical practice, and related ethical issues. It also provides an overview of some of the new findings related to research involving placebos and the possible associated ethical challenges.
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