Two separate genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with social and nonsocial autistic-like traits. We predicted that we would find SNPs associated with social and non-social autistic-like traits and that different SNPs would be associated with social and nonsocial. In Stage 1, each study screened for allele frequency differences in approximately 430,000 autosomal SNPs using pooled DNA on microarrays in high-scoring versus low-scoring boys from a general population sample (N = approximately 400/group). In Stage 2, 22 and 20 SNPs in the social and non-social studies, respectively, were tested for QTL association by individually genotyping an independent community sample of 1,400 boys. One SNP (rs11894053) was nominally associated (P < .05, uncorrected for multiple testing) with social autistic-like traits. When the sample was increased by adding females, 2 additional SNPs were nominally significant (P < .05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797846 | PMC |
| http://dx.doi.org/10.1007/s10519-009-9308-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Differential late-stage face processing in autism: a magnetoencephalographic study of fusiform gyrus activation.
BMC Psychiatry
December 2024
Gillberg Neuropsychiatry Centre, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Background: Autism is associated with alterations of social communication, such as during face-to-face interactions. This study aimed to probe face processing in autistics with normal IQ utilizing magnetoencephalography to examine event-related fields within the fusiform gyrus during face perception.
Methods: A case-control cohort of 22 individuals diagnosed with autism and 20 age-matched controls (all male, age 29.
Nebulized vasopressin penetrates CSF and improves social cognition without inducing aggression in a rhesus monkey model of autism.
Proc Natl Acad Sci U S A
December 2024
California National Primate Research Center, Davis, CA 95616.
Low cerebrospinal (CSF) arginine vasopressin (AVP) concentration is a biomarker of social impairment in low-social monkeys and children with autism, suggesting that AVP administration may improve primate social functioning. However, AVP administration also increases aggression, at least in "neurotypical" animals with intact AVP signaling. Here, we tested the effects of a voluntary drug administration method in low-social male rhesus monkeys with high autistic-like trait burden.
View Article and Find Full Text PDFMultimodal imaging of the amygdala in non-clinical subjects with high vs. low autistic-like social skills traits.
Psychiatry Res Neuroimaging
January 2025
Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), Marburg, Germany. Electronic address:
Article Synopsis
- Recent research indicates that impairments in social skills and theory of mind related to autism spectrum disorder (ASD) exist on a continuum among the general population, from typical individuals to those with ASD.
- This study involved 56 non-clinical participants divided into high and low autistic-like social skill traits, examining amygdala function and structure through various imaging techniques.
- Results showed that individuals with high social skill traits exhibited increased blood perfusion and different activation patterns in the amygdala when processing fearful faces, suggesting overlapping neurological features between those with typical social functioning and ASD patients.
Prenatal maternal subjective distress predicts higher autistic-like traits in offspring: The Iowa Flood Study.
Dev Psychopathol
October 2024
Douglas Mental Health University Institute, Montreal, QC, Canada.
Article Synopsis
- Autism prevalence in the U.S. more than increased fourfold from 2000 to 2020, prompting research into factors that contribute to autistic traits in children.
- A study focused on children exposed to prenatal maternal stress (PNMS) during a natural disaster (2008 Iowa floods) found that a mother's subjective distress significantly predicted the severity of autistic-like traits in her children.
- The study revealed that maternal distress during pregnancy had a lasting impact on these traits from ages 4 to 7, while other factors like objective hardship or timing didn't show significant effects.
Superior temporal sulcus folding, functional network connectivity, and autistic-like traits in a non-clinical population.
Mol Autism
October 2024
Cognitive Neuropsychiatry Lab, Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Rudolf-Bultmann-Str. 8, 35037, Marburg, Germany.
Background: Autistic-like traits (ALT) are prevalent across the general population and might be linked to some facets of a broader autism spectrum disorder (ASD) phenotype. Recent studies suggest an association of these traits with both genetic and brain structural markers in non-autistic individuals, showing similar spatial location of findings observed in ASD and thus suggesting a potential neurobiological continuum.
Methods: In this study, we first tested an association of ALTs (assessed with the AQ questionnaire) with cortical complexity, a cortical surface marker of early neurodevelopment, and then the association with disrupted functional connectivity.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!