Engineering the mouse genome to model human disease for drug discovery.

Methods Mol Biol

Ozgene Pty. Ltd., Bentley DC, WA, Australia.

Published: February 2010

Genetically engineered mice (GEM) have become invaluable tools for human disease modeling and drug development. Completion of the mouse genome sequence in combination with transgenesis and gene targeting in embryonal stem cells have opened up unprecedented opportunities. Advanced technologies for derivation of GEM models will be introduced and discussed.

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-60761-058-8_4DOI Listing

Publication Analysis

Top Keywords

mouse genome
8
human disease
8
engineering mouse
4
genome model
4
model human
4
disease drug
4
drug discovery
4
discovery genetically
4
genetically engineered
4
engineered mice
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!