Viral and fungal colitides are rare in the immunocompetent host but are most clinically significant in populations with compromised immune function. They may be associated with high mortality, particularly when treatment is delayed. It is important to be aware of these diseases when treating patients with colitis to allow early diagnosis and treatment, which will improve outcome.
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http://dx.doi.org/10.1055/s-2007-970197 | DOI Listing |
Food Microbiol
August 2025
Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Guangzhou, Guangdong, 510070, China; Key Laboratory of Big Data Technologies for Food Microbiological Safety, State Administration for Market Regulation, NHC Specialty Laboratory of Food Safety Risk Assessment and Standard Development, Guangzhou, Guangdong, 510070, China. Electronic address:
Human norovirus (HuNoV) and human sapovirus (HuSaV) are the common foodborne viruses that can be transmitted through the consumption of contaminated shellfish. With the rise of e-commerce, these platforms have become an important channel for Chinese consumers to purchase seafood products. However, the potential impact of this new commercial model on viral contamination necessitates further investigation.
View Article and Find Full Text PDFVirology
March 2025
Institute for Animal Health & UK-China Centre of Excellence for Research on Avian Diseases, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, People's Republic of China; Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, People's Republic of China. Electronic address:
Ferroptosis is an iron-dependent form of programmed cell death that plays a crucial role in regulating intracellular redox homeostasis and lipid metabolism, and in combating viral infections. Viruses have persistently evolved and adapted synergistically with their hosts over a long period and, to some extent, have been able to utilize ferroptosis to promote viral replication. Herein, we summarize the characteristics, mechanisms, and regulatory networks of ferroptosis and provide an overview of the key regulatory steps of ferroptosis involved in viral infection, together with the changes in host indicators and key regulatory signaling pathways.
View Article and Find Full Text PDFSci Adv
March 2025
Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Obeldesivir (ODV; GS-5245) is an orally administered ester prodrug of the parent nucleoside GS-441524 that has broad spectrum antiviral activity inhibiting viral RNA-dependent RNA polymerases. We recently showed that ODV completely protects cynomolgus macaques against lethal infection with Sudan virus when given 24 hours after parenteral exposure. Here, we report that once daily oral ODV treatment of cynomolgus and rhesus macaques for 10 days confers 80 and 100% protection, respectively, against lethal Ebola virus infection when treatment is initiated 24 hours after mucosal (conjunctival) exposure.
View Article and Find Full Text PDFMicrob Genom
March 2025
Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.
(SA) is an opportunistic pathogen and human commensal that is frequently present in the upper respiratory tract, gastrointestinal tract and skin. While SA can cause diseases ranging from minor skin infections to life-threatening bacteraemia, it can also be carried asymptomatically. Indigenous individuals in the Southwest USA experience high rates of invasive SA disease.
View Article and Find Full Text PDFMol Divers
March 2025
Growdea Technologies Pvt. Ltd., Gurugram, Haryana, 122004, India.
Neuraminidase (NA) is an essential enzyme located at the outer layer of the influenza virus and plays a key role in the release of virions from infected cells. The rising incidence of global epidemics has made the urgent need for effective antiviral medications an urgent public health priority. Furthermore, the emergence of resistance caused by specific mutations in the influenza viral genome exacerbates the challenges of antiviral therapy.
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