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Enhancer-driven Shh signaling promotes glia-to-mesenchyme transition during bone repair.
Bone Res
January 2025
Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, Jiangsu Province, China.
Plp1-lineage Schwann cells (SCs) of peripheral nerve play a critical role in vascular remodeling and osteogenic differentiation during the early stage of bone healing, and the abnormal plasticity of SCs would jeopardize the bone regeneration. However, how Plp1-lineage cells respond to injury and initiate the vascularized osteogenesis remains incompletely understood. Here, by employing single-cell transcriptional profiling combined with lineage-specific tracing models, we uncover that Plp1-lineage cells undergoing injury-induced glia-to-MSCs transition contributed to osteogenesis and revascularization in the initial stage of bone injury.
View Article and Find Full Text PDFSuppression of TLR4/NF-κB signaling by kaurenoic acid in a mice model of monosodium urate crystals-induced acute gout.
Arch Biochem Biophys
January 2025
Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address:
Aim: The aim of the current study was to investigate the potential therapeutic effect of kaurenoic acid (KA) against Monosodium Urate Crystals (MSU)- induced acute gout by downregulation of NF-κB signaling pathway, mitigating inflammation and oxidative stress produced by MSU crystals. KA potentially targeted NF-κB pathway activation and provided comprehensive insights through multiple approaches. This was accomplished by advanced analytical techniques.
View Article and Find Full Text PDFRight Ventricular Outflow Tract Obstruction: Transcatheter Correction In Tetralogy Of Fallot: A Pilot Study.
Am J Cardiol
January 2025
Department of Anaesthesiology, All India Institute of Medical Sciences, Kalyani, Kolkata.
This study evaluated transcatheter approach for relieving right ventricular outflow tract (RVOT) obstruction using combined non-compliant balloon dilatation of the RVOT and conal artery occlusion in patients with Tetralogy of Fallot (TOF), both uncorrected and post-intra-cardiac repair (ICR) restenosis. A prospective study was conducted from January 2022 to June 2023, including 40 symptomatic patients aged over 12 years with RVOT obstruction in TOF. Exclusion criteria included moderate to severe pulmonary regurgitation.
View Article and Find Full Text PDFConsensus recommendations for measuring the impact of contraception on the menstrual cycle in contraceptive clinical trials.
Contraception
January 2025
MSI Reproductive Choices, London, England, United Kingdom.
Objective: We sought to develop consensus recommendations for measurement and analysis of data on contraceptive-induced menstrual changes (CIMCs) in contraceptive clinical trials. We built upon previous standardization efforts over the last 50 years and prioritized input from a variety of global experts and current regulatory authority guidance on patient-reported outcomes.
Study Design: We completed a formal consensus-building process with an interdisciplinary group of 57 experts from 30 organizations and 14 countries in five global regions who work across academia, nonprofit research organizations, the pharmaceutical industry, and funding agencies.
Iron oleate containing lipid nanoparticles prepared by gradient solvent diffusion method for oxidative stress dependent antibacterial therapy.
Int J Pharm
January 2025
School of Pharmacy, Changzhou University, Changzhou 213164, Jiangsu, PR China. Electronic address:
This study was designed to assess the efficacy of iron oleate lipid nanoparticles (IO-LNPs) in inducing Fenton reaction as a therapeutic approach for bacterial infections caused by Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), both of which are common pathogens in skin wound infections.
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