Direct binding of WD40 repeat of Embryonic Ectoderm Development (EED) in the Polycomb Repressor Complex 2 (PRC2) to the histone H3 tail regulates the H3K27 methyltrasnferase activity of PRC2. The binding activity is required for the methylation of H3K27 over long distance of a Drosophila chromosome from the UBX (Hox gene) promoter to the PBX upstream enhancer region, implying EED initiates propagation of this repressive mark.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283120 | PMC |
| http://dx.doi.org/10.1093/jmcb/mjp046 | DOI Listing |
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