Using Bartonella henselae isolates from cats and a human, the activity of pradofloxacin was compared with those of enrofloxacin and azithromycin. By Etest and disc diffusion assay, pradofloxacin showed greater antimicrobial activity than did other antibiotics. We conclude that pradofloxacin may prove useful for the treatment of B. henselae infections.
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http://dx.doi.org/10.1128/JCM.01287-09 | DOI Listing |
Aust Vet J
September 2024
Cat Specialist Services, Underwood, Queensland, Australia.
A 12-year-old female spayed Domestic Shorthair cat presented with a 4-day history of lethargy, inappetence and vomiting. Physical findings included a grade 2/6 heart murmur and cranial abdominal pain on palpation. Serum biochemistry revealed elevated total bilirubin and liver enzymes activities.
View Article and Find Full Text PDFMicroorganisms
May 2024
Department of Clinical Microbiology, Royal University Hospital and Saskatchewan Health Authority, Saskatoon, SK S7N 0W8, Canada.
Pradofloxacin is the newest of the veterinary fluoroquinolones to be approved for use in animals-initially companion animals and most recently food animals. It has a broad spectrum of in vitro activity, working actively against Gram-positive/negative, atypical and some anaerobic microorganisms. It simultaneously targets DNA gyrase (topoisomerase type II) and topoisomerase type IV, suggesting a lower propensity to select for antimicrobial resistance.
View Article and Find Full Text PDFAntibiotics (Basel)
September 2022
Department of Comparative Biomedical Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield AL9 7TA, UK.
Fluoroquinolones (FQ) are commonly used in dogs with bacterial skin infections. Their use as first choice, along with the increased incidence of FQ-resistance, represents a risk to animal and public health. Our study determined minimum inhibitory (MIC) and bactericidal (MBC) concentrations of five FQs in , and together with FQ-resistance mechanisms.
View Article and Find Full Text PDFJ Vet Pharmacol Ther
March 2022
Sydney School of Veterinary Science, The University of Sydney, Sydney, NSW, Australia.
Fluoroquinolones are often administered to pet rabbits given their perceived safety and limited effects on anaerobic gut microbiota. However, the pharmacokinetics and relative safety of pradofloxacin, a third-generation veterinary fluoroquinolone with a much broader spectrum of activity, have not been reported in this species. Here, we determined the pharmacokinetic profile of a single dose of oral pradofloxacin in rabbits and evaluated effects on the faecal microbiome.
View Article and Find Full Text PDFVet Dermatol
December 2019
Animal Dermatology Clinic, 2965 Edinger Ave, Tustin, CA, 92780, USA.
Background: Moxifloxacin is a fourth-generation fluoroquinolone (FQ) that is approved for use in people to treat a variety of infections. Some veterinary microbiology laboratories report moxifloxacin in culture and sensitivity profiles for Staphylococcus pseudintermedius and S. schleiferi albeit using Clinical & Laboratory Standards Institute (CLSI) breakpoints for S.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!