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Iontophoresis Improves the Impact on the Quality of Life of Children with Primary Hyperhidrosis-A Prospective Study and a Short Review.
Children (Basel)
October 2024
Clinical Medical Department, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University, 800008 Galati, Romania.
Background: Primary hyperhidrosis (PH) is a somatic and idiopathic pediatric skin disease. The eccrine glands are tiny and very numerous, with approximately 3 million distributed throughout the skin. There is no commonly accepted amount of sweating to define hyperhidrosis, but people with this disease suffer real limitations integrating into society, which can be quantified through quality of life measurement scales.
View Article and Find Full Text PDFIontophoresis and electroporation-assisted microneedles: advancements and therapeutic potentials in transdermal drug delivery.
Drug Deliv Transl Res
October 2024
College of Sciences and Mathematics, Department of Biomedical Sciences, Auburn University, Auburn, AL, 36849, USA.
Article Synopsis
- - Transdermal drug delivery (TDD) using electrically assisted microneedle (MN) systems is gaining attention as a better option compared to traditional methods, focusing on recent developments in various therapies.
- - By combining iontophoresis (IP) and electroporation (EP) with MN technology, these systems have shown improved treatment outcomes in areas like vaccine delivery, diabetes management, dermatology, NSAID administration, and more.
- - Despite some challenges regarding safety and technology, ongoing research is looking to enhance these methods for wider use in personalized medicine and innovative therapeutic applications.
Permeation characteristics and cross-linking efficacy of iontophoresis-assisted riboflavin delivery for accelerated riboflavin-ultraviolet A scleral collagen cross-linking in porcine eyes.
Exp Eye Res
November 2024
College of Biomedical Engineering, Taiyuan University of Technology, Jinzhong, 030600, China. Electronic address:
Article Synopsis
- The study explores the effectiveness of iontophoresis-assisted riboflavin delivery for treating the posterior sclera compared to traditional passive soaking in terms of delivery time and riboflavin permeation efficiency.
- Researchers applied riboflavin solutions into porcine eye sclerae using both methods over varying time intervals of 5 to 20 minutes and analyzed riboflavin distribution using fluorescence microscopy.
- Results showed that while iontophoresis led to higher riboflavin concentration at shorter times (12.5 and 15 minutes) compared to passive soaking, both methods provided similar mechanical strength in the sclera, suggesting that iontophoresis could reduce treatment time without sacrificing effectiveness in collagen cross-linking.
The Influence of the COVID-19 Pandemic on the Addressability to Treatment of Children with Hyperhidrosis-A Retrospective Study and a Short Review.
Life (Basel)
August 2024
Clinical Medical Department, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University, 800008 Galati, Romania.
Article Synopsis
- This study investigates how the COVID-19 pandemic negatively impacted the ability of patients to receive iontophoresis treatment for hyperhidrosis, a condition that causes excessive sweating.
- It is a retrospective analysis conducted in Romania that reviewed data from 111 patients treated between 2013 and 2023, revealing a complete drop in patient visits during the pandemic.
- The study highlights that despite the debilitating effects of hyperhidrosis on quality of life, patients and their families often do not see it as a pressing health issue needing immediate treatment.
Primary Hyperhidrosis in Children-A Retrospective Study and a Short Review.
Life (Basel)
May 2024
Multidisciplinary Integrated Center of Dermatological Interface Research MIC-DIR (Centrul Integrat Multidisciplinar de Cercetare de Interfata Dermatologica-CIM-CID), Dunărea de Jos University, 800201 Galati, Romania.
Primary hyperhidrosis (PH) is a relatively common chronic disorder, characterized by significant and uncontrollable sweating. The predominant areas of occurrence are hands, feet, head and armpits, and it affects both men and women equally, with a false impression of increased prevalence in women. This study aims to determine the incidence of cases of hyperhidrosis, the gender of the patients and the environment of origin and to identify the most affected age groups and the distribution of hyperhidrosis, as well as creating a curve of cases within the time interval studied and their comparison with those in the specialized literature.
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