Spirodiketopiperazine-based CCR5 antagonists, showing improved pharmacokinetic profiles without reduction in antagonist activity, were designed and synthesized. We also demonstrate the anti-HIV activity of a representative compound 12, as measured in a p24 assay.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553643 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2009.11.018 | DOI Listing |
Publication Analysis
Top Keywords
spirodiketopiperazine-based ccr5
8
ccr5 antagonists
8
pharmacokinetic profiles
8
antagonists improvement
4
improvement pharmacokinetic
4
profiles spirodiketopiperazine-based
4
antagonists showing
4
showing improved
4
improved pharmacokinetic
4
profiles reduction
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!