The quest for formaldehyde substitutes is motivated by two fundamental developments: the OSHA regulation standard declaring it hazardous and advocating its substitution with less dangerous chemicals and the fact that formalin is a poor preserver of nucleic acids. Among the non-alcoholic formalin substitute, glyoxal has been hailed as the best alternative. In this work, we showed that glyoxal-containing fixatives are not plausible polyvalent substitution options.
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[Glyoxal: a possible polyvalent substitute for formaldehyde in pathology?].
Ann Pathol
December 2009
Equipe d'accueil signalisation et génomique fonctionnelle en recherche translationnelle oncologique, service d'anatomie et cytologie pathologiques, hôpitaux de Brabois, CHU de Nancy, université de Nancy, 5, allée du Morvan, 54511 Vandoeuvre-lès-Nancy, France.
The quest for formaldehyde substitutes is motivated by two fundamental developments: the OSHA regulation standard declaring it hazardous and advocating its substitution with less dangerous chemicals and the fact that formalin is a poor preserver of nucleic acids. Among the non-alcoholic formalin substitute, glyoxal has been hailed as the best alternative. In this work, we showed that glyoxal-containing fixatives are not plausible polyvalent substitution options.
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