Synthesis and in vivo evaluation of bicyclic gababutins.

Bioorg Med Chem Lett

Sandwich Laboratories, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.

Published: January 2010

Synthesis of a number of bicyclic five-membered ring derivatives of gabapentin led to the identification of two compounds, (-)-(11A) and (20A) which both had an excellent level of potency against alpha(2)delta and were profiled in an in vivo model of neuropathic pain.

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http://dx.doi.org/10.1016/j.bmcl.2009.11.118DOI Listing

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