AI Article Synopsis
- The thyroid gland is crucial for life, and research shows it contains stem/progenitor cells that may aid in tissue regeneration and cancer development.
- Recent studies focus on the differentiation of thyroid cells from embryonic stem cells and the role of adult thyroid stem/progenitor cells in both healthy and cancerous thyroids, along with potential sources like bone marrow.
- Understanding these stem cell populations is vital for developing targeted therapies in thyroid disease and cancer treatment.
Article Abstract
Background: Thyroid gland development and function are essential for life, and recent findings indicate the presence of stem/progenitor cells within the thyroid gland as a potential source of tissue regeneration and cancer formation.
Summary: This review summarizes the current knowledge on early differentiation of thyroid cells from embryonic stem cells and highlights exciting concepts and recent novel findings on adult thyroid stem/progenitor cells in the normal thyroid gland and in thyroid cancer. Other potential sources and markers of stem/progenitor cells in the thyroid include bone marrow, microchimerism, and embryological remnant-derived multifocal solid cell nests. Finally, we discuss new therapeutic strategies that target thyroid cancer stem cells.
Conclusions: Thyroid stem/progenitor cell populations are present in the normal and diseased thyroid gland. Advances in normal and cancer thyroid stem cell biology will be essential for future targeted therapies.
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| http://dx.doi.org/10.1089/thy.2009.1604 | DOI Listing |
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