In a non-linguistic analog of the "cocktail-party" scenario, informational and contextual factors were found to affect the recognition of everyday environmental sounds embedded in naturalistic auditory scenes. Short environmental sound targets were presented in a dichotic background scene composed of either a single stereo background scene or a composite background scene created by playing different background scenes to the different ears. The side of presentation, time of onset, and number of target sounds were varied across trials to increase the uncertainty for the participant. Half the sounds were contextually congruent with the background sound (i.e., consistent with the meaningful real-world sound environment represented in the auditory scene) and half were incongruent. The presence of a single competing background scene decreased identification accuracy, suggesting an informational masking effect. In tandem, there was a contextual pop-out effect, with contextually incongruent sounds identified more accurately. However, when targets were incongruent with the real-world context of the background scene, informational masking was reduced. Acoustic analyses suggested that this contextual pop-out effect was driven by a mixture of perceptual differences between the target and background, as well as by higher-level cognitive factors. These findings indicate that identification of environmental sounds in naturalistic backgrounds is an active process that requires integrating perceptual, attentional, and cognitive resources.
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Sci Rep
January 2025
School of Cyberspace Security, Hebei University of Engineering Science, Shijiazhuang, 050091, China.
Aerial images can cover a wide area and capture rich scene information. These images are often taken from a high altitude and contain many small objects. It is difficult to detect small objects accurately because their features are not obvious and are susceptible to background interference.
View Article and Find Full Text PDFHarm Reduct J
January 2025
Asociación Bajacaliforniana de Salud Pública A.C, Tijuana, Baja California, Mexico.
Background: Xylazine is a α2-adrenergic receptor agonist, used for sedation in veterinary contexts. Although it is increasingly found in overdose deaths across North America, the clinical management of xylazine-involved overdoses has not been extensively studied, especially in community-based harm reduction settings. Here we present a clinical series of xylazine-involved overdose and share the clinical approach and lessons learned by a community overdose response team in Tijuana, Mexico amidst the arrival of xylazine.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Yale School of Medicine, New Haven, CT, USA.
Background: Affective cognition and emotion processing is impaired in amnestic Alzheimer's disease (AD), although less is known about atypical (AT) variants such as logopenic variant primary progressive aphasia (lvPPA) and posterior cortical atrophy (PCA). The affective blindsight pathway bypasses V1 via the superior colliculus-pulvinar route to activate the amygdala in cases of occipital lesioning and may explain maintenance of emotion identification and visual information processing in non-amnestic AD despite atrophy in visuospatial regions. We sought to characterize functional connectivity from key regions along the affective blindsight pathway in a clinically heterogeneous AD cohort.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Stony Brook University, Stony Brook, NY, USA.
Background: Family history of Alzheimer's disease (AD) or undiagnosed memory problems is linked to an increased risk of dementia. Subjective memory complaints are also more common among individuals with positive family history, which could be indicative of heightened awareness of memory deficits in these people. Here, we conducted an online study in cognitively normal individuals across the lifespan and aimed to examine whether the presence of family history is linked to worse objective memory performance that mediates the lower subjective memory in these individuals.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Background: Frequent and remote cognitive assessment may improve sensitivity to subtle cognitive decline associated with preclinical Alzheimer's disease (AD). Our objective was to evaluate the feasibility, reliability, and construct validity of repeated remote memory assessment in late middle-aged and older adults.
Method: Participants were recruited from longitudinal aging cohorts to complete medial temporal lobe-based memory paradigms (Object-In-Room Recall [ORR], Mnemonic Discrimination for Objects and Scenes [MDT-OS], Complex Scene Recognition [CSR]) using the neotiv application on a smartphone or tablet at repeated intervals over one year.
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