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Quorum Sensing Inhibitors: An Alternative Strategy to Win the Battle against Multidrug-Resistant (MDR) Bacteria.
Molecules
July 2024
Hospital Pharmacy, Giovanni Paolo II Hospital, ASL Gallura, 07026 Olbia, Italy.
Antibiotic resistance is a major problem and a major global health concern. In total, there are 16 million deaths yearly from infectious diseases, and at least 65% of infectious diseases are caused by microbial communities that proliferate through the formation of biofilms. Antibiotic overuse has resulted in the evolution of multidrug-resistant (MDR) microbial strains.
View Article and Find Full Text PDFFor the Forthcoming Winning Shot in the Battle against Cushing Disease.
Endocrinol Metab (Seoul)
August 2024
Department of Endocrinology and Metabolism, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea.
Louis Pasteur (1822-1895), Ignaz Semmelweis (1818-1865), Joseph Lister (1827-1912) and the Link Between Their Works Toward the Development of Antisepsis: A Narrative Review.
Cureus
June 2024
History of MEdicine and Medical Ethics, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.
Infection control remains a significant burden for healthcare systems. The irrational use of antibiotics in the fight against microbial diseases has led to the fast development of antimicrobial resistance. Considering how the latter can adversely influence the effectiveness of modern treatments and the way medicine is practiced, we should revise the events that led to the establishment of the general principles of antisepsis and pay special tribute to the people who contributed to their formation, bearing in mind that they remain unmodified to a great extent until today.
View Article and Find Full Text PDFNon-pharmacological interventions for diabetic peripheral neuropathy: Are we winning the battle?
World J Diabetes
April 2024
Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Preston PR2 9HT, United Kingdom.
Despite the advent of relatively reliable modalities of diagnosing diabetic peripheral neuropathy (DPN), such as nerve conduction studies, there is still a knowledge gap about the pathophysiology, and thus limited available interventions for symptom control and curtailing disease progression. The pharmacologic aspect of management is mainly centred on pain control, however, there are several important aspects of DPN such as loss of vibration sense, pressure sense, and proprioception which are associated with risks to lower limb health, which pharmacotherapy does not address. Furthermore, published evidence suggests non-pharmacologic interventions such as glycaemic control through dietary modification and exercise need to be combined with other measures such as psychotherapy, to reach a desired, however modest effect.
View Article and Find Full Text PDFWinning the Battle of Timely Guideline-Directed Medical Therapy Titration.
JACC Heart Fail
April 2024
Department of Biomedical Informatics and Data Sciences, Yale School of Medicine, New Haven, Connecticut, USA.
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