Objectives/hypothesis: To increase awareness of torture among otolaryngologists, and to describe methods and complications of head and neck torture.
Study Design: Retrospective review.
Methods: Five cases of survivors of torture were evaluated in an otolaryngology practice in an urban hospital setting.
Results: The subjects presented with widely variable symptoms and physical manifestations related to the head and neck as a result of torture, in addition to psychiatric disease. Documentation of head and neck findings were essential to the asylum claim.
Conclusions: Otolaryngologists serving immigrant and refugee populations must be familiar with methods and manifestations of torture involving the head and neck.
Oral squamous cell carcinoma (OSCC) is the most frequent type of oral malignancy with high metastasis and poor prognosis. The deubiquitinating enzyme Ubiquitin Specific Peptidase 44 (USP44) regulates the mitotic checkpoint, and its deficiency leads to aneuploidy and increases tumor incidence. However, the role of USP44 in OSCC is not well understood.
The Japanese Society of Oral Oncology and Japanese Society of Oral and Maxillofacial Surgeons have jointly developed clinical practice guidelines for oral cancer (oral squamous cell carcinoma) to improve and standardize the quality of oral cancer treatment in Japan. The first, second, and third editions were published in 2009, 2013, and 2019, respectively, and the 2023 edition was recently developed. In the development of the 2023 edition, 60 clinical questions (CQs) were listed.
Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Università degli Studi di Brescia, Brescia, Italy; Unit of Otorhinolaryngology, Head and Neck Surgery, Azienda Socio Sanitaria Territoriale Spedali Civili Di Brescia, Brescia, Italy.
Objectives: This study aims to validate and assess the reliability of the Arabic version of the Voice Handicap Index-Throat (VHI-T), as a self-reported questionnaire for patients with throat difficulties.
Study Design: A prospective, observational, cross-sectional, and descriptive study was performed in the ear, nose, and throat department of Kafr El-Sheikh University hospitals from October 2023 to July 2024.
Methods: The preliminary VHI-T was obtained through forward and backward translation.
Introduction: Despite significant successes, immune checkpoint blockade fails to achieve clinical responses in a significant proportion of patients, predictive markers for responses are imperfect and immune-related adverse events (irAEs) are unpredictable. We used T-cell receptor (TCR) sequencing to systematically analyze prospectively collected patient blood samples from a randomized clinical trial of dual immune checkpoint inhibitor therapy to evaluate changes in the T-cell repertoire and their association with response and irAEs.
Methods: Patients with immunotherapy-naïve metastatic non-small cell lung cancer (NSCLC) were treated with ipilimumab and nivolumab according to trial protocol (LONESTAR, NCT03391869).
The objective of this study was to examine the relationship between the insulin-like peptide 3 (INSL3) receptor (RXFP2) expression levels on spermatozoa and INSL3 concentrations in the seminal plasma of fresh semen from beef bulls with different levels of sperm morphological normality. Ejaculates (n = 44) were collected from 21 yearling Japanese Black beef bulls and categorized into three groups based on the levels of sperm morphological normality: High (normal morphology ≥ 80%; n = 23), Mid (< 80% & ≥ 65%; n = 10) and Low (< 65%; n = 11). Immunofluorescence was used to determine the localization and expression levels of RXFP2 in spermatozoa.
