Clinical Question: Analysis to date on the impact of a pronounced skeletal dentofacial deformity on quality of life remains inadequate.
Objective: The objective of this study was to introduce a validated and internationally comparable questionnaire for the assessment of quality of life, and to use this questionnaire in a consecutively-selected patient cohort.
Material And Methods: The Orthognathic Quality of Life Questionnaire (OQLQ) used internationally was translated into German and adapted in accordance with EU guidelines (OQLQ-G). A total of 50 patients (f = 25, m = 25) indicated for combined orthodontic and surgical treatment were included in the study. In addition to the assessment of individual questions, the patients were classified according to the following categories: (1) perception of the malocclusion, (2) masticatory function, (3) esthetics, and (4) social aspects. The statistics were assessed with software SPSS((R)) 15.0 (chi-squared test; p = 0.05).
Results: Patients with a pronounced dentofacial malocclusion demonstrated a considerably high awareness of the degree of the deformity. Responses frequently included severe and very severe functional restrictions (50.4%) and/or esthetic impairment (43.0%). With regard to social aspects, the responders also reported a reduction in quality of life.
Conclusion: An internationally-comparable assessment of quality of life in patients with a pronounced jaw discrepancy was carried out for German-speaking countries. This pilot study demonstrates that their quality of life is significantly impaired.
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http://dx.doi.org/10.1007/s00056-009-9903-4 | DOI Listing |
Phys Ther
January 2025
IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
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JAMA Netw Open
January 2025
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Importance: Secondary lymphedema is a common, harmful side effect of breast cancer treatment. Robust risk models that are externally validated are needed to facilitate clinical translation. A published risk model used 5 accessible clinical factors to predict the development of breast cancer-related lymphedema; this model included a patient's mammographic breast density as a novel predictive factor.
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January 2025
Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari "Aldo Moro", Bari, Italy.
Background: In their interesting systematic review, Gallehzan et al. quoted our article Cost-utility analysis of teriflunomide in naïve vs. previously treated patients with relapsing-remitting multiple sclerosis (RRMS) in Italy.
View Article and Find Full Text PDFReprod Sci
January 2025
Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Jinan University, 601 Huangpu Rd, Guangzhou, 510632, PR China.
High-fructose and high-fat diet (HFHFD) has been associated with impaired spermatogenesis, leading to decreased sperm quality and increased male infertility, with similar effects observed in offspring. Cyanidin-3-O-glucoside (C3G), a recognized food antioxidant, has shown promise in protecting in male reproduction and modulating epigenetic modifications. However, its potential role in ameliorating intergenerational inheritance induced by HFHFD remains underexplored.
View Article and Find Full Text PDFPlant Mol Biol
January 2025
School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan, 411201, China.
Deficiency or excess of mineral elements in the environment is a primary factor limiting crop yields and nutritional quality. Lotus (Nelumbo nucifera) is an important aquatic crop in Asia, but the mechanism for accumulating mineral nutrients and coping with nutrient deficiency/excess is still largely unknown. Here, we identified NnMTP10, a member of the cation diffusion facilitator family, by screening the cDNA library of lotus.
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