AI Article Synopsis
- The study measured serum levels of advanced oxidation protein products (AOPPs) and glycation end products (AGEs) in patients with liver cirrhosis to understand their relationship with liver function, indicated by Child-Pugh and MELD scores.
- Patients with decompensated liver cirrhosis (Child-Pugh B and C) had significantly higher AOPP levels compared to compensated cirrhosis patients and healthy controls, while AGEs were also elevated in all cirrhotic patients.
- Additionally, lower antioxidant levels were found in cirrhotic patients, and strong correlations were noted between AOPP levels, oxidative stress, and MELD scores, suggesting that AOPPs may play a role in oxidative stress and disease
Article Abstract
Serum concentrations of advanced oxidation protein products (AOPPs) and glycation end products (AGEs) were assessed with respect to functional compromise of liver, as determined by the Child-Pugh and MELD scores. Patients with decompensated liver cirrhosis (Child-Pugh B and C) exhibited significantly higher serum concentrations of AOPPs than both patients with compensated liver cirrhosis (Child-Pugh A) and controls. The levels of plasma AGEs in all liver cirrhotic patients were higher when compared with those with the controls and this difference was statistically significant. Plasma total antioxidant status of the patients was significantly lower than that of controls. Significant positive correlations between AOPPs level and the MELD score and between the oxidative stress index and the MELD score were found in all patients with liver cirrhosis. Altered AOPPs levels in decompensated patients may influence the potency of oxidative stress and the progression of liver disease.
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