We present a systematic theoretical study of core-satellite gold nanoparticle assemblies using the Generalized Multiparticle Mie formalism. We consider the importance of satellite number, satellite radius, the core radius, and the satellite distance, and we present approaches to optimize spectral shift due to satellite attachment or release. This provides clear strategies for improving the sensitivity and signal-to-noise ratio for molecular detection, enabling simple colorimetric assays. We quantify the performance of these strategies by introducing a figure of merit. In addition, we provide an improved understanding of the nanoplasmonic interactions that govern the optical response of core-satellite nanoassemblies.
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http://dx.doi.org/10.1063/1.3254756 | DOI Listing |
Anal Methods
December 2024
School of Biomedical Engineering, International University, Ho Chi Minh City 700000, Vietnam.
Telomerase activity has piqued scientists' interest for the reason that it has the potential to be employed for early-stage cancer detection, anticancer therapy and studies related to cancer progression and metastasis. Several approaches have been developed to detect telomerase activity. However, these approaches were lengthy, challenging to quantify, of limited sensitivity and prone to polymerase chain reaction (PCR)-related artefacts.
View Article and Find Full Text PDFNanotechnology
October 2024
National Research Center for High-Efficiency Grinding, College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, People's Republic of China.
Three-dimensional (3D) free-standing nanostructures based on electron-beam lithography (EBL) have potential applications in many fields with extremely high patterning resolution and design flexibility with direct writing. In numerous EBL processes designed for the creation of 3D structures, the multilayer resist system is pivotal due to its adaptability in design. Nevertheless, the compatibility of solvents between different layers of resists often restricts the variety of feasible multilayer combinations.
View Article and Find Full Text PDFMicromachines (Basel)
September 2024
Department of Mechanical Engineering and Advanced Institute of Manufacturing with High-Tech Innovations, National Chung Cheng University, Chiayi 621301, Taiwan.
DNA is fundamental for storing and transmitting genetic information. Analyzing DNA or RNA base sequences enables the identification of genetic disorders, monitoring gene expression, and detecting pathogens. Traditional detection techniques like polymerase chain reaction (PCR) and next-generation sequencing (NGS) have limitations, including complexity, high cost, and the need for advanced computational skills.
View Article and Find Full Text PDFNanoscale Adv
September 2024
Department of Electro-Optics and Photonics Engineering, School of Electrical and Computer Engineering and The Ilse-Katz Institute for Nano-scale Science and Technology, Ben Gurion University Beer Sheva 84105 Israel
Surface-enhanced Raman scattering (SERS) is recognized as a powerful analytical method. However, its efficacy is hindered by considerable signal variability stemming from factors like surface irregularities, temporal instability of the substrate, interference with substrate signal, polarization sensitivity and uneven molecular distribution. To address these challenges, a new strategy is employed to enhance the reproducibility of SERS signals.
View Article and Find Full Text PDFNano Lett
September 2024
General Surgery Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children's Health, Hangzhou 310052, China.
Bradyarrhythmia poses a serious threat to human health, with chronic progression causing heart failure and acute onset leading to sudden death. In this study, we develop a scalable drug-mimicking nanoplasmonic therapeutic strategy by introducing gold nanorod (Au NR) mediated near-infrared (NIR) photothermal effects. An integrated sensing and regulation platform is established for in situ synchronized NIR laser regulation and electrophysiological property recording.
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