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Deep Learning Analysis of White Matter Hyperintensity and its Association with Comprehensive Vascular Factors in Two Large General Populations.
J Imaging Inform Med
January 2025
Department of Convergence Medicine, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Seoul, 05505, Republic of Korea.
Although the relationships between basic clinical parameters and white matter hyperintensity (WMH) have been studied, the associations between vascular factors and WMH volume in general populations remain unclear. We investigated the associations between clinical parameters including comprehensive vascular factors and WMH in two large general populations. This retrospective, cross-sectional study involved two populations: individuals who underwent general health examinations at the Asan Medical Center (AMC) and participants from a regional cohort, the Korean Genome and Epidemiology Study (KoGES).
View Article and Find Full Text PDFImaging biomarker associated with early neurological deterioration in isolated pontine infarction.
Front Neurol
December 2024
Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Objective: To investigate the association between cerebral small vessel disease burden, along with its individual imaging features, as well as other imaging features and early neurological deterioration in isolated pontine infarction.
Methods: 107 patients with acute isolated pontine infarcts, within 24 h of symptom onset, were retrospectively analyzed. The mean age of the participants was 67 years.
High-risk characteristics of recurrent ischemic stroke after intensive medical management for 6-month follow-up: a histogram study on vessel wall MRI.
Eur Radiol
January 2025
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Objective: Intensive medical management has been recommended for ischemic stroke of intracranial atherosclerosis (ICAS), but 9.4-15% probability of recurrent stroke remains an inevitable reality. The characteristics of high-risk intracranial plaque that contribute to stroke recurrence after intensive therapy are unclear.
View Article and Find Full Text PDFSynopsis: White matter hyperintensities are abnormalities that appear in MRI scans of living patients but are not apparent in MRI post-mortem.
Goal: Our goal is to understand the cellular/biological basis of white matter hyperintensities (WMH).
Approach: We aligned post-mortem MR scans with those collected ante-mortem and performed histopathology and pyrGC/MS for plastics on regions with WMH.
Assessing stroke recurrence in sICAS: a study on mCSVD score and culprit plaque magnetic resonance characteristics.
Front Neurol
November 2024
Department of Medical Imaging, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Background: Recurrent ischemic stroke in patients with symptomatic intracranial atherosclerotic stenosis (sICAS) can be attributed to two main causes: intracranial atherosclerotic stenosis (ICAS) and cerebral small vessel disease (CSVD). This study investigates the potential associations between stroke recurrence and the modified cerebral small vessel disease (mCSVD) burden score, as well as the characteristics of culprit plaques related to intracranial artery high-resolution vessel wall imaging (HR-VWI).
Methods: A total of 145 patients presenting sICAS underwent intracranial artery HR-VWI and routine cranial MRI at two large Chinese hospitals from December 2019-2022 were participants of this retrospective analysis.
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