The check of dosimetry of the intraoperative radiotherapy system Intrabeam is predefined by the manufacture (Zeiss). The purpose of the study was to develop and implement a method to verify the internal dosimetry of Intrabeam (Zeiss). Additionally the long-term stability of Intrabeam was checked for dose and isotropy. For dose to water measurements an Unidos was combined with a soft jet chamber (TM 23342) which was calibrated in water absorbed dose and as a phantom the type 2962 (PTW Freiburg) was used. RW1 plates were inserted as build up material. The applicators were placed in a bag filled with water to consider the side-scattering. At the surface of the applicator there was a mean difference of 3 percent between the dose to water measurement and the internal dosimetry. The constancy of the dose rate showed a mean deviation of 0.3% at the reference point. The analysis of the dose distribution perpendicular to the applicator axis z (reference z-axis) resulted in a mean deviation of -2.7% (x-direction) and -7,1% (-x-direction) for the x-axis and, respectively -4.1% (y-direction) and -5.3% (-y-direction) for the y-axis. The proposed method is suitable to verify the absolute dose of Intrabeam. The dose values measured by this method were congruent to the dosimetry of the manufacture (Zeiss). From our point of view it is sufficient to verify the absolute dosimetry only at time of commissioning of the system or in the case of changing the applicator. For the daily routine the check of constancy specified by the manufacture is adequate, because the dose rate is checked on a daily basis. Additionally the test of constancy showed a high long-term stability in terms of dose rate and symmetry.
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http://dx.doi.org/10.1016/j.zemedi.2009.09.001 | DOI Listing |
Cureus
December 2024
Clinical Pharmacology, Botanic Tonics, LLC, Calabasas, USA.
This study investigates the safety of three different daily dosages of a liquid blend containing kava and kratom (Feel Free® Classic Tonic {FFCT}) in healthy adults over six consecutive days of supplementation. Both kava and kratom have been used traditionally for hundreds of years, but there is limited data on the combined safety of these ingredients. In this randomized, double-blind, placebo-controlled trial, the participants were assigned to receive one of three daily dosages of FFCT or placebo.
View Article and Find Full Text PDFDrug Alcohol Depend Rep
March 2025
Institute for Drug and Alcohol Studies, Virginia Commonwealth University, 203 East Cary Street, Richmond, VA 23219, USA.
Background: Evidence supports the common incidence of sleep disturbance in opioid use disorder (OUD) as a potential marker of disrupted orexin system functioning. This study evaluated the initial safety and tolerability of a challenge dose of lemborexant, a dual orexin antagonist, as an adjunct to buprenorphine/naloxone.
Methods: Patients (18-65 years old) with OUD receiving sublingual buprenorphine/naloxone, with a Pittsburgh Sleep Quality Index total score of 6 or higher, were recruited from outpatient clinics.
Drug Des Devel Ther
January 2025
Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.
Introduction: The mechanism of remimazolam, a benzodiazepine that activates γ-aminobutyric acid a (GABAa) receptors, in cerebral ischemia/reperfusion (I/R) injury is not well understood. Therefore, we explored whether remimazolam activates protein kinase B (AKT)/glycogen synthase kinase-3β (GSK-3β)/nuclear factor erythroid 2-related factor 2 (NRF2) to attenuate brain I/R injury in transcerebral I/R-injured rats and transoxygenic glucose deprivation/reperfusion (OGD/R)-injured SY5Y cells.
Material And Methods: Remimazolam was added at the beginning of cell and rat reperfusion, and the PI3K/AKT inhibitor LY294002 was added to inhibit the AKT/GSK-3β/NRF2 pathway 24 h before cellular OGD/R treatment and 30 min before rat brain I/R treatment.
J Tradit Complement Med
January 2025
Institute of Food Science and Technology, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan.
Background And Aim: (CM) and (AM) are medicinal mushrooms with potential applications in the treatment of mood disorders, including depression and anxiety. While research suggests that both CM and AM possess anti-inflammatory properties and hold potential for treating depression when administered separately, there is limited knowledge about their efficacy when combined in a formula, as well as the underlying mechanism involving the modulation of microglia.
Experimental Procedure: Rats received oral administrations of the low-dose formulation, medium-dose formulation, and high-dose formulation over 28 consecutive days as part of the UCMS protocols.
J Tradit Complement Med
January 2025
Department of Chinese Medicine, China Medical University Hospital, Taichung City, 40447, Taiwan.
Background: Recent research has established an association between insomnia and an elevated risk of stroke. Given the severe global impact of stroke on public health, exploring nonpharmacological interventions, such as acupuncture, that can mitigate stroke risk among individuals with insomnia is crucial.
Methods: In this retrospective cohort study, we used data from the Taiwan National Health Insurance Database (NHIRD) to examine the relationship between acupuncture and the risk of stroke among individuals who received a diagnosis of insomnia between 2000 and 2017.
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