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Clinical characteristics and serological profiles of Lyme disease in children: a 15-year retrospective cohort study in Switzerland.
Lancet Reg Health Eur
January 2025
Division of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Background: Lyme disease (LD) is caused by and is the most common tickborne disease in the northern hemisphere. Although classical characteristics of LD are well-known, the diagnosis and treatment are often delayed. Laboratory diagnosis by serological testing is recommended for most LD manifestations.
View Article and Find Full Text PDFEvaluation of the Epitogen Lyme Detect IgG ELISA: a novel peptide multiplexing approach.
Microbiol Spectr
October 2024
EpitogenX Ltd, Foresterhill Health Campus, Aberdeen, United Kingdom.
Article Synopsis
- Lyme Borreliosis (LB), or Lyme disease, is increasingly concerning due to its severe health risks from untreated cases, often diagnosed too late with current tests having low sensitivity.
- A new diagnostic test, the Epitogen Lyme Detect IgG ELISA, was validated in this study using 220 serum samples to assess sensitivity and specificity against the standard LIAISON Borrelia IgG test.
- The Epitogen test showed comparable performance for late stages of LB and significantly higher sensitivity for early suspected cases, indicating it could improve early and accurate diagnosis of Lyme disease.
Bridging the gap: Insights in the immunopathology of Lyme borreliosis.
Eur J Immunol
December 2024
Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (Bbsl) genospecies transmitted by Ixodes spp. ticks, is a significant public health concern in the Northern Hemisphere. This review highlights the complex interplay between Bbsl infection and host-immune responses, impacting clinical manifestations and long-term immunity.
View Article and Find Full Text PDFCurrent and emerging approaches for eliminating and alleviating persistent Lyme disease symptoms.
Front Microbiol
September 2024
Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, United States.
Article Synopsis
- Lyme disease is the most common tick-borne infection in North America, primarily caused by Borrelia bacteria, with notable differences in manifestations and treatments compared to Europe.
- Early diagnosis of Lyme disease is challenging due to non-specific symptoms and limitations of current FDA-approved tests, especially when there's no prior tick bite or characteristic rash.
- Although most patients respond well to antibiotic treatment, around 10-20% experience lingering symptoms known as post-treatment Lyme disease syndrome (PTLDS), with poorly understood causes and contributing factors.
Skin Changes in Suspected Lyme Disease.
Acta Dermatovenerol Croat
December 2023
Pero Vržogić, MD, Naftalan Special Hospital for Medical Rehabilitation, Ivanić Grad, Croatia;
Article Synopsis
- Ticks are a significant health concern in Croatia and worldwide due to their role in transmitting various diseases, including Lyme borreliosis, which is caused by the Borrelia burgdorferi bacterium.
- In Croatia, the incidence rate of Lyme borreliosis is approximately 6.51 cases per 100,000 people, highlighting the risk of infection from ticks.
- The article describes a case of a 58-year-old woman with Lyme disease who had skin manifestations that fully regressed after successful treatment, demonstrating the importance of early diagnosis and intervention.
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