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A new LNC89/LNC60-Col11a2 axis revealed by whole-transcriptome analysis may be associated with goiters related to excess iodine nutrition.
Front Endocrinol (Lausanne)
November 2024
Key Lab of Etiology and Epidemiology, National Health Commission & Education Bureau of Heilongjiang Province (23618504), Key Laboratory of Trace Elements and Human Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.
Goiter related to excessive iodine nutrition remains a significant public health issue in some countries. There has been no reported study on long noncoding RNAs (lncRNAs) related to goiters. In this study, goiter was induced by drinking water with excess iodine for 10 or 20 weeks in Kunming mice.
View Article and Find Full Text PDFEffects of high fluoride and iodine combined exposure on thyroid nodules and goiter in school-age children in Jiangsu, China.
Heliyon
November 2024
Department for Environmental Health (Endemic Disease Control and Prevention), Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Road 172, 210009 Nanjing, PR China.
Introduction: With advancements in detection equipment and an increase in the frequency of examinations, thyroid nodules and goiter in children have garnered attention.
Objective: This study aims to determine the effects of high iodine and fluoride exposure on thyroid nodules and goiter in school-aged children.
Methods: We recruited children aged 8 to 12 from rural Jiangsu, China, based on the concentrations of iodine and fluoride in local drinking water and urine.
Causes of abortion in Iranian goat herds and associated risk factors.
Prev Vet Med
January 2025
Animal Pathology Department, Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), Veterinary Faculty of Zaragoza, C/Miguel Servet 177, Zaragoza 50013, Spain.
Abortion imposes a substantial economic burden on the global small ruminant industry, not only reducing herd productivity but also contributing to the spread of zoonotic diseases. This study examines the primary factors associated with abortion, both infectious and non-infectious, in 623 goat herds across Iran. A comprehensive evaluation was performed, incorporating herd history, laboratory results, and statistical analyses using univariate tests and multivariable binary logistic regression.
View Article and Find Full Text PDFTight Junctions and Cancer: Targeting Claudin-1 and Claudin-4 in Thyroid Pathologies.
Pharmaceuticals (Basel)
September 2024
Chair of Pathology, Dr Jan Biziel University Hospital No. 2, 85-168 Bydgoszcz, Poland.
Article Synopsis
- Claudins, specifically claudin-1 and claudin-4, are tight junction proteins involved in the progression of thyroid cancers and are potential therapeutic targets.
- The study analyzed 162 thyroid samples from patients with various pathologies, finding distinct expression patterns: goiters had negative claudin-1 and mostly positive claudin-4, while papillary thyroid cancers and adenomas showed positive claudin-1 and claudin-4.
- High expression levels of claudin-1 were linked to poorer overall survival rates in patients, highlighting its role as a prognostic factor and indicating a need for further trials to explore claudin targeting in clinical settings.
A History of the Elimination of Iodine Deficiency Disorders in the Americas: A Dramatic Achievement and Lessons Learned.
J Nutr
December 2024
Section of Endocrinology, Diabetes, and Nutrition, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, United States. Electronic address:
Iodine is essential for the synthesis of thyroid hormones, which regulate cell metabolism, growth, and development. Although iodine deficiency (ID) causes adverse health effects across the lifespan, it is particularly problematic in pregnancy, when it can lead to irreversible fetal brain damage. A high prevalence of severe ID, manifesting as endemic goiter and cretinism, predated the arrival of European explorers in the Americas.
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