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Melanotic Neuroectodermal Tumour of Infancy.
Head Neck Pathol
June 2023
Department of Oral & Maxillofacial Surgery, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, AIMS Campus, Kochi, India.
Article Synopsis
- Melanotic neuroectodermal tumour of infancy (MNTI) is a mostly benign, locally aggressive tumor that primarily affects infants under one year old, particularly in the head and neck region, with the anterior maxilla being the most common site.
- The tumor consists of two types of cells: neuroblastic and pigmented epithelial cells, and while it appears benign, it can invade surrounding tissues like muscle and bone, complicating diagnosis.
- Treatment typically involves surgical excision, which is usually effective, but early diagnosis is crucial to avoid complications related to growth and reconstruction in infants.
Congenital Melanotic Macule of the Tongue: Report of Two Cases and Literature Review.
Head Neck Pathol
June 2023
Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, R. Rodolpho Paulo Rocco, n. 325, 1st floor, Rio de Janeiro, RJ, Brazil.
Background: Congenital melanotic macule of the tongue (CMMT) has been described as a distinct entity, despite its unknown etiology. However, the diagnosis and management of affected newborns may challenge clinicians and pediatric dentists.
Methods: We document here the clinicopathological findings of two additional cases of CMMT.
Melanotic medullary thyroid carcinoma: A case report with review of the literature.
Diagn Cytopathol
January 2023
Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Melanotic medullary thyroid carcinoma is morphologically defined by the presence of melanin deposits in the cytoplasm of tumor cells. It is an extremely rare variant with only 15 cases described in the literature to date and only one report of diagnosis by fine needle aspiration (FNA) biopsy. A 51-year-old woman presented with neck swelling.
View Article and Find Full Text PDFMelanotic neuroectodermal tumor of infancy (MNTI) - A rare entity.
J Cancer Res Ther
August 2022
Department of Peadriatic Surgery, KGMU, Lucknow, Uttar Pradesh, India.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy is a rare and aggressive pigmented tumor primarily found in the maxilla of infants, distinguished by its neural crest origin and diverse cellular markers.
- The tumor grows rapidly and destructively, leading to a high likelihood of recurrence and malignant transformation if left untreated.
- In a case study, a 2-month-old boy underwent successful wide local excision and chemotherapy, showing promising recovery without signs of recurrence or metastasis during follow-up.
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours.
Head Neck Pathol
March 2022
Department of Diagnostic Sciences, School of Dentistry, Texas A&M University, Dallas, TX, USA.
The 5 edition of the World Health Organization (WHO) Classification of Head and Neck Tumours (2022) comes out only five years after the previous edition, however it presents important updates that run in parallel with the rapid progression involving the increasingly sophisticated molecular investigation and its interpretation, some of which already have therapy-related impact. This manuscript provides an overview of the leading changes introduced in the classification of Odontogenic and Maxillofacial Bone Tumours that encompasses cysts of the jaws, odontogenic tumours, giant cell lesions and bone cysts, and bone and cartilage tumours. This is the first edition that Essential and Desirable Diagnostic Features were added for each entity, so that the most important clinical, microscopic and/or radiologic features were encapsulated and briefly highlighted.
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