This literature review and survey highlights the controversies surrounding the significance of joint sounds in general, the problems and pitfalls of joint sound analysis and interpretation, and the degree of importance given peripheral and temporomandibular joint sounds by physicians and dentists. The instrumentation and devices currently proposed for use in the detection and interpretation of joint sounds may not meet the standards of validity, reliability, sensitivity, and specificity, and as pointed out by one investigator, "The only objectivity currently associated with these instruments is their ability to record sounds of undetermined origin." In addition, no solid evidence is available that these particular sounds, when detected, are both repeatable over time and distinctly characteristic for particular disorders or significant pathologic changes. Some degree of caution should be used, therefore, when interpreting joint sounds in the absence of significant signs and symptoms of temporomandibular disorders. The clinical significance of these same sounds may become more or less apparent relative to the information obtained in a comprehensive temporomandibular disorder evaluation and examination including both subjective and objective pain assessments, mandibular range of motion measurements, and the interpretation of radiologic findings.
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J Nanobiotechnology
January 2025
Department of Ultrasound, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, China.
Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenging because of its depth, which often leads to misdiagnosis during ultrasound examinations. The unique PDAC tumor microenvironment (TME) is characterized by significant fibrous tissue growth, and high interstitial pressure hinders drug penetration into tumors. Additionally, hypoxia and immune suppression within the tumor contribute to poor responses to radiotherapy and chemotherapy, ultimately leading to an unfavorable prognosis.
View Article and Find Full Text PDFLife (Basel)
January 2025
Department of Rehabilitation Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA.
Background: High-velocity, low-amplitude (HVLA) manipulation is a common manual therapy technique used for treating pain and musculoskeletal dysfunction. An audible manipulation sound is commonly experienced by patients who undergo HVLA manipulation; however, there is little known about the effects and clinical relevance of the audible manipulation sound on cortical output and the autonomic nervous system. This study aimed to identify the immediate impact of the audible manipulation sound on brainwave activity and pupil diameter in asymptomatic subjects following an HVLA cervical manipulation.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Joint R&D Center for Metallic Materials, Metallic Wire and Metallic Card Clothing, Xi'an 710021, China.
The mechanical properties of music wire are contingent upon its microstructure, which in turn influences its applications in music. Chinese stringed instruments necessitate exacting standards for comprehensive performance indexes, particularly with regard to the strength, resilience, and rigidity of the musical steel wires, which differ from the Western approach to musical wire. In this study, SWP-B music wire was selected for investigation through metal heat treatment, which was employed to regulate its microstructure characteristics.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Graduate School of Advanced Science and Engineering, Hiroshima University, Hiroshima 739-8527, Japan.
Application of high-heat input welding on high-tensile strength steels causes deterioration of mechanical properties of the welded joint, due to softening and grain coarsening in the heat-affected zone (HAZ). In this study, low-heat input narrow-gap hot-wire laser welding was applied to 12 mm thick 780 MPa-class high-tensile strength steel plate. Conditions were optimized based on microstructural observations of joints produced at various welding speeds.
View Article and Find Full Text PDFQuant Imaging Med Surg
January 2025
Department of Ultrasound, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Background: Traditional 2-dimensional (2D) ultrasound is a noninvasive method in the assessment of glomerular disease. Ultrasound elastography shows promise in evaluating renal fibrosis, which plays a key role in glomerular disease progression. However, research in pediatric cohorts is limited.
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