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Creativity and Mental Illness: A Case Study of a Patient with Progressive Bulbar Palsy.
Brain Sci
November 2024
Clinical Neuroanatomy, Department of Neurology, University Hospital Ulm, 89081 Ulm, Germany.
Creativity and the production of artwork can have an impact on the course and treatment of comorbid severe mental illness and neurodegeneration. We report on a 70-year-old male patient with highly original artistic behavior, who suffered from lifelong recurrent major depression and subsequently developed symptoms of progressive bulbar palsy (PBP). In the context of a systematic literature review, we detail the patient's personal and artistic biographies and portray artwork from his artistic portfolio together with his disease history, clinical examination, psychopathological and neuropsychological evaluations, blood and cerebrospinal fluid analyses, neuroimaging, neurophysiological testing, and psychotherapeutic treatment.
View Article and Find Full Text PDFGuillain-Barré syndrome (GBS) is characterized classically by progressive and symmetrical motor weakness and areflexia. We describe a case of GBS with initially preserved reflexes and power, leading to delayed diagnosis, who latterly required urgent ventilator support and plasmapharesis to highlight the importance of considering atypical presentations of this common condition.
View Article and Find Full Text PDFOnset of age, site and respiratory symptoms are strongly associated with respiratory decline in sporadic amyotrophic lateral sclerosis: a long-term longitudinal study.
BMJ Neurol Open
December 2024
Aichi Medical University, Nagakute, Aichi, Japan.
Objective: The objective of this study is to identify factors influencing progression of respiratory decline from the onset of neurological symptoms to respiratory failure in patients with amyotrophic lateral sclerosis (ALS).
Methods: In 100 patients with sporadic ALS, %vital capacity (%VC) was continuously measured from the first visit to the respiratory endpoint (REP). Cox proportional hazards model identified factors influencing the duration from onset of ALS to REP (Onset-REP).
Motor Neuron Diseases and Central Nervous System Tractopathies: Clinical-Radiologic Correlation and Diagnostic Approach.
Radiographics
January 2025
From the Departments of Radiology (A.B.D., A.A., E.H.M., A.A.B., V.G.) and Neurology (A.S.M., K.H.M., S.L.C.), Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224; Department of Neurology, Mayo Clinic, Rochester, MN (N.K., E.S., E.P.F.); and Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy (E.S.).
Article Synopsis
- * Amyotrophic lateral sclerosis (ALS) is the most common acquired motor neuron disease, with multiple variants affecting different motor neuron types; characteristic MRI features include T2 hyperintensities along key areas of the brain.
- * Other conditions, including toxic, metabolic, genetic, and infectious diseases, can also damage corticospinal tracts, leading to upper motor neuron injury symptoms, which can be identified through MRI imaging.
Colistin induced neurotoxicity with bulbar palsy. A case report and literature review.
IDCases
November 2024
Hospital Medicine Department, Integrated Hospital Care Institute, Cleveland Clinic Abu-Dhabi, PO BOX: 112412, Abu-Dhabi, United Arab Emirates.
Colistin, a polymyxin antibiotic, is increasingly used to manage infections caused by multidrug-resistant gram-negative bacteria. This case report documents the occurrence of colistin-induced neurotoxicity manifesting as bulbar palsy in a 38-year-old male with a complex medical history. The patient, presenting with septic shock secondary to a diabetic foot ulcer, was administered colistin and meropenem, leading to a progressive onset of neurological symptoms.
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