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Intron retention as a productive mechanism in human MAPT: RNA species generated by retention of intron 3.
EBioMedicine
February 2024
Anatomy, Histology and Neuroscience Department, School of Medicine, Universidad Autónoma de Madrid (UAM), 28029, Madrid, Spain; Graduate Programa in Neuroscience, Universidad Autónoma de Madrid (UAM), 28029, Madrid, Spain; Networking Research Centre on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029, Madrid, Spain; Institute for Molecular Biology-IUBM (Universidad Autónoma de Madrid), 28049, Madrid, Spain. Electronic address:
Background: Tau is a microtubule-binding protein encoded by the MAPT gene. Tau is essential for several physiological functions and associated with pathological processes, including Alzheimer's disease (AD). Six tau isoforms are typically described in the central nervous system, but current research paints a more diverse landscape and a more nuanced balance between isoforms.
View Article and Find Full Text PDFSignalling pathways involved in the chemotactic activity of CXCL12 in cultured rat cerebellar neurons and CHP100 neuroepithelioma cells.
J Neuroimmunol
February 2003
Dipartimento di Fisiologia Umana e Farmacologia, Università di Roma La Sapienza Piazzale Aldo Moro, 5, I-00185, Rome, Italy.
We compared the signal transduction pathways activated by stromal cell-derived factor-1 (CXCL12) chemokine in two different cell systems: primary cultures of rat cerebellar granule neurons (CGN) and human neuroepithelioma CHP100 cells. Both cell types express functional CXC chemokine receptor 4 (CXCR4), which is coupled both to extracellular signal-regulated kinase (ERK) and Akt phosphorylation pathways. The activation of ERK shows different dependency on the phosphatidylinositol 3-kinase (PI3-K) pathway and different sensitivity to pertussis toxin (PTX) treatment, indicative of coupling to different G proteins in the two cell systems considered.
View Article and Find Full Text PDFNeuroepithelioma of the soft tissues of the right parietotemporal region in the 25-year-old male patient is described. The tumor grew through the cranial bones into the dura mater. The patient died 1.
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