Conversion of oximes to carbonyl compounds with 2-nitro-4,5-dichloropyridazin-3(2H)-one.

J Org Chem

Department of Chemistry & Environmental Biotechnology National Core Research Center, Research Institute of Natural Sciences, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University, Jinju 660-701, Korea.

Published: January 2010

Conversion of oximes to the carbonyl compounds has been demonstrated with use of 2-nitro-4,5-dichloropyridazin-3(2H)-one (2) under microwave irradiated conditions. Fourteen aliphatic and aromatic oximes converted to their corresponding aldehydes and ketones in good to excellent yields. It is noteworthy that the reaction is conducted under neutral, mild, and eco-friendly condition.

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo902356eDOI Listing

Publication Analysis

Top Keywords

conversion oximes
8
oximes carbonyl
8
carbonyl compounds
8
compounds 2-nitro-45-dichloropyridazin-32h-one
4
2-nitro-45-dichloropyridazin-32h-one conversion
4
compounds demonstrated
4
demonstrated 2-nitro-45-dichloropyridazin-32h-one
4
2-nitro-45-dichloropyridazin-32h-one microwave
4
microwave irradiated
4
irradiated conditions
4

Similar Publications

Photocatalytic Partial Water Oxidation Promoted by a Hydrogen Acceptor-Hydroxyl Mediator Couple.

Adv Sci (Weinh)

December 2024

Soochow Institute for Energy and Materials InnovationS (SIEMIS), Soochow University, Suzhou, 215006, China.

Hydrogen peroxide (HO) is an important chemical in synthetic chemistry with huge demands. Photocatalytic synthesis of HO via oxygen reduction and water oxidation reactions (ORR and WOR) is considered as a promising and desirable solution for on-site applications. However, the efficiency of such a process is low due to the poor solubility of molecular oxygen and the rapid reverse reaction of hydroxyl radicals (OH) with hydrogen atoms (H).

View Article and Find Full Text PDF

Ambient Synthesis of Cyclohexanone Oxime via In Situ Produced Hydrogen Peroxide over Cobalt-Based Electrocatalyst.

Adv Sci (Weinh)

December 2024

Key Laboratory of Materials Physics, Centre for Environmental and Energy Nanomaterials, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, HFIPS, Chinese Academy of Sciences, Hefei, 230031, China.

Cyclohexanone oxime, a critical precursor for nylon-6 production, is traditionally synthesized via the hydroxylamine method under industrial harsh conditions. Here is present a one-step electrochemical integrated approach for the efficient production of cyclohexanone oxime under ambient conditions. This approach employed the coupling of in situ electro-synthesized HO over a cobalt (Co)-based electrocatalyst with the titanium silicate-1 (TS-1) heterogeneous catalyst to achieve the cyclohexanone ammoximation process.

View Article and Find Full Text PDF

ConspectusIn the past decade, single-atom skeletal editing, which involves the precise insertion, deletion, or exchange of single atoms in the core skeleton of a molecule, has emerged as a promising synthetic strategy for the rapid construction or diversification of complex molecules without laborious synthetic processes. Among them, carbene-initiated skeletal editing is particularly appealing due to the ready availability and diverse reactivities of carbene species. The initial endeavors to modify the core skeleton of heteroarenes through carbon-atom insertion could date back to 1881, when Ciamician and Denstedt described the conversion of pyrroles to pyridines by trapping haloform-derived free carbene.

View Article and Find Full Text PDF

Broccoli is recognized for its health benefits, attributed to the high concentrations of glucoraphanin (GR). GR must be hydrolyzed by myrosinase (Myr) to form the bioactive sulforaphane (SF). The primary challenge in delivering SF in the upper gastrointestinal (GI) tract- is improving hydrolysis of GR to SF.

View Article and Find Full Text PDF

Highly Efficient Synthesis of α-Amino Acids via Electrocatalytic C-N Coupling Reaction Over an Atomically Dispersed Iron Loaded Defective TiO.

Adv Mater

December 2024

State Key Laboratory of Chem/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, 410082, P. R. China.

The synthesis of α-amino acids via the electrocatalytic C-N coupling attracted extensive attention owing to the mild reaction conditions, controllable reaction parameters, and atom economy. However, the α-amino acid yield remains unsatisfying. Herein, the efficient electrocatalytic synthesis of α-amino acids is achieved with an atomically dispersed Fe loaded defective TiO monolithic electrocatalyst (Fe-TiO/Ti).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!