The fungus Phaeosphaeria spartinae is an endophyte of the marine alga Ceramium sp. Investigation of this marine-derived fungus led to the isolation of the new natural products spartinol A (1), B (2), C (3) and D (4). The structures of these closely related compounds were established from extensive spectroscopic investigations. Compound 3 showed weak inhibition of human leukocyte elastase (HLE).
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