Introduction: Northern Ontario, like many rural and remote regions around the world, has a chronic shortage of health professionals. Recognizing that medical graduates who have grown up in rural areas are more likely to practice in rural settings, the Government of Ontario, Canada established a new medical school with a social accountability mandate to contribute to improving the health of the peoples and communities of Northern Ontario.
Background: The Northern Ontario School of Medicine (NOSM) is a joint initiative of Laurentian University in Sudbury and Lakehead University in Thunder Bay, cities one thousand kilometers apart. The NOSM model of medical education is built on several recent educational developments including rural-based medical education, social accountability of medical education and electronic distance education. This paper describes these developments as background to presenting the Northern Ontario School of Medicine as a socially accountable, geographically distributed rural-based medical school. NOSM MD PROGRAM: The school actively seeks to recruit students for the MD program from Northern Ontario or similar northern, rural, remote, Aboriginal, and Francophone backgrounds. The holistic, cohesive curriculum is grounded in Northern Ontario and relies heavily on broadband electronic communications to support distributed, community engaged learning. Students, both in classroom and clinical settings, explore cases as if they were physicians in Northern Ontario communities. Clinical education takes place in a wide range of community and health service settings so that students can experience the diversity of communities and cultures in Northern Ontario.
Conclusion: Although NOSM is still in the early stages of development, there are encouraging signs that the school's evidence-based model of medical education will be successful in developing a sustainable, community responsive health workforce for Northern Ontario.
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Kidney Int
January 2025
Laboratório de Fisiopatologia Renal (LIM 16), Nephrology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Universidade de São Paulo, São Paulo, Brazil. Electronic address:
In 2017, Kidney Disease: Improving Global Outcomes (KDIGO) published a Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Since then, new lines of evidence have been published related to evaluating disordered mineral metabolism and bone quality and turnover, identifying and inhibiting vascular calcification, targeting vitamin D levels, and regulating parathyroid hormone. For an in-depth consideration of the new insights, in October 2023, KDIGO held a Controversies Conference on CKD-MBD: Progress and Knowledge Gaps Toward Personalizing Care.
View Article and Find Full Text PDFBr J Dermatol
January 2025
Department of Dermatology, Yale University, New Haven, Connecticut, USA.
Background: Overexpression of interleukin (IL)-17A and IL-17F significantly influences psoriasis pathology. Until recently, biologics targeting IL-17A alone, like secukinumab, were used to treat psoriasis. Bimekizumab is a monoclonal IgG1 antibody that targets both IL-17A and IL-17F.
View Article and Find Full Text PDFCancers (Basel)
January 2025
Algoma District Cancer Program, Sault Area Hospital, Sault Ste. Marie, ON P6B 0A8, Canada.
Background: Colorectal cancer primarily affects older adults and poses treatment challenges due to age-related comorbidities and frailty, which hinder surgical and chemotherapy options for many elderly patients. This study aims to analyze treatment and disease patterns in elderly colorectal cancer patients, aged over 80 years old, to inform personalized therapies that accommodate their unique clinical needs and improve their outcomes.
Patients And Methods: The medical records of all patients aged 80 years old and above, and those aged 65 to 75 years old, who were diagnosed with colorectal cancer at a cancer center in Canada over a seven year period, were retrospectively reviewed.
BJU Int
January 2025
CHU de Québec-Université Laval, Quebec City, Quebec, Canada.
Objective: To conduct the first meta-analysis using only prospective studies to evaluate whether video endoscopic inguinal lymphadenectomy (VEIL) offers advantages in perioperative outcomes compared to open IL (OIL) in patients with penile cancer.
Methods: A systematic review with meta-analysis was conducted across multiple databases, including Cochrane Central Register of Controlled Trials (CENTRAL), the Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica dataBASE (EMBASE), Latin America and Caribbean Health Sciences Literature (LILACS), Scopus, Web of Science, and several trial registries up to June 2024. Only randomised controlled trials (RCTs) and prospective cohort studies were included.
J Environ Sci (China)
July 2025
Department of Chemistry, Faculty of Science, University of Alberta, 11227 Saskatchewan Dr NW, Edmonton, Alberta, T6G 2G2, Canada; Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2G3, Canada. Electronic address:
We report here arsenic speciation in 1643 freshwater fish samples, representing 14 common fish species from 53 waterbodies in Alberta, Canada. Arsenic species were extracted from fish muscle tissue. Arsenic species in the extracts were separated using anion-exchange high-performance liquid chromatography (HPLC) and quantified using inductively coupled plasma mass spectrometry (ICPMS).
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