Objective: To describe and characterise the Audio Recorded Cognitive Screen (ARCS), a novel instrument that uses an audio device to administer selected neuropsychological tests to unsupervised individuals who write their responses in a special booklet for later scoring.
Methods: The ARCS was administered to 733 individuals, comprising 550 from a normative community sample (mean age=59.14, range 18-84 years), 101 clinic patients and a separate validation sample of 82 community controls, who, together with the patients, underwent detailed neuropsychological assessments. These data were examined for the influence of demographic variables on ARCS performance, to establish normal performance and develop scoring routines, and to characterise the structure, reliability and validity of the instrument.
Results: Age, gender and education influenced ARCS performance. ARCS tests were generally reliable and correlated well with corresponding conventional neuropsychological tests. Factor analyses indicated that the ARCS measures executive functioning/attention, memory, language, verbal fluency and visuospatial functioning. The ARCS discriminated well between normal (n=82), impaired (n=33) and demented (n=25) individuals, and significantly better than did the Mini Mental State Examination (MMSE), including on a single, demographically adjusted, global QuickARCS score obtainable in about 3 min of the clinician's time. Receiver Operating Characteristic analyses confirmed the superiority of the ARCS over MMSE as a screen for mild dementia (AUC 0.98, 99% CI 0.95 to 1.00) or cognitive impairment (AUC 0.90, 99% CI 0.83 to 0.97).
Conclusions: The ARCS has good validity and reliability, has a sound normative base and measures functioning in multiple cognitive domains while imposing minimal time demands upon the clinician.
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http://dx.doi.org/10.1136/jnnp.2009.188003 | DOI Listing |
Heliyon
July 2024
School of Business Information Technology, University of Economics, Ho Chi Minh City, Viet Nam.
In this manuscript, we first initiate several types of effective arcs of intuitionistic fuzzy directed graphs, followed by discussions on different types of dominations in intuitionistic fuzzy directed graphs and their application in decision-making. The notion of dominations in fuzzy graphs, fuzzy directed graphs, intuitionistic fuzzy graphs and picture fuzzy graphs have been extensively discussed in the literature. Thus, the work presented in our study is two-fold: on one side, it extends the notion of domination in fuzzy directed graphs, while on the other side, it fills the gap existing in the literature.
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Cataracts remain the leading cause of visual impairment worldwide, yet the underlying molecular mechanisms, particularly in age-related cataracts (ARCs), are not fully understood. The Notch signaling pathway, known for its critical role in various degenerative diseases, may also contribute to ARC pathogenesis, although its specific involvement is unclear. This study investigates the role of Notch signaling in regulating ferroptosis in lens epithelial cells (LECs) and its impact on ARC progression.
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