AI Article Synopsis
- The study examined the prevalence of obstructive sleep apnea (OSA) in kidney transplant patients and those on the waiting list, finding similar rates of OSA in both groups.
- A total of 100 transplant and 50 waiting list patients were assessed through polysomnography, revealing varying levels of OSA severity in both groups.
- OSA was linked to higher body mass index, age, and neck circumference among transplant patients, who also required more antihypertensive medications, indicating a potential connection between OSA and hypertension in kidney transplant recipients.
Article Abstract
Background And Objectives: We assessed the prevalence of obstructive sleep apnea (OSA) and its clinical correlates in a large sample of patients who received a kidney transplant (Tx). We also compared the prevalence of the disorder between dialysis patients who were on the waiting list for a Tx (WL) and Tx patients.
Design, Setting, Participants, & Measurements: This was a cross-sectional study of 100 Tx and 50 WL patients who underwent one-night polysomnography (SLeep disorders Evaluation in Patients after kidney Transplantation [SLEPT] Study). Sociodemographic information and data about medication, comorbidity, and laboratory parameters were collected.
Results: The prevalence of mild (apnea-hypopnea index [AHI] > or =5/h and <15/h), moderate (AHI > or =15/h and <30/h), and severe OSA (AHI > or =30/h) was 18, 11, and 14% in the Tx group and 28, 16, and 10% in the WL group, respectively. The AHI was significantly correlated with age (rho = 0.34), body mass index (rho = 0.45), neck circumference (rho = 0.4), abdominal circumference (rho = 0.51), and hemoglobin (rho = 0.24) in the Tx group. The proportion of Tx patients who were treated with three or more antihypertensive drugs was significantly higher in the OSA group (56 versus 31%; P = 0.022). Despite taking significantly more antihypertensive drugs, the average systolic BP was still higher in patients with versus without OSA (147 +/- 21 versus 139 +/- 18 mmHg; P = 0.059).
Conclusions: The prevalence of OSA is similar in Tx and WL patients and it may contribute to presence of hypertension in patients who receive a Tx.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801644 | PMC |
| http://dx.doi.org/10.2215/CJN.04030609 | DOI Listing |
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