Presented paper describes a system of biomedical signal classifiers with preliminary feature extraction stage based on matched wavelets analysis, where two structures of classifier using Neural Networks (NN) and Support Vector Machine (SVM) are applied. As a pilot study the rules extraction algorithm applied for two of mentioned machine learning approaches (NN & SVM) was used. This was made to extract and transform the representation of knowledge gathered in Black Box parameters during classifier learning phase to be better and natural understandable for human user/expert. Proposed system was tested on the set of ECG signals of 20 atrial fibrillation (AF) and 20 control group (CG) patients, divided into learning and verifying subsets, taken from MIT-BiH database. Obtained results showed, that the ability of generalization of created system, expressed as a measure of sensitivity and specificity increased, due to extracting and selectively choosing only the most representative features for analyzed AF detection problem. Classification results achieved by means of constructed matched wavelet, created for given AF detection features were better than indicators obtained for standard wavelet basic functions used in ECG time-frequency decomposition.
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http://dx.doi.org/10.1109/IEMBS.2009.5334220 | DOI Listing |
BMC Med Inform Decis Mak
December 2024
Nivel, Netherlands Institute for Health Services Research, Otterstraat 118, Utrecht, 3513 CR, The Netherlands.
Background: At the beginning of the COVID-19 pandemic in 2020, little was known about the spread of COVID-19 in Dutch nursing homes while older people were particularly at risk of severe symptoms. Therefore, attempts were made to develop a nationwide COVID-19 repository based on routinely recorded data in the electronic health records (EHRs) of nursing home residents. This study aims to describe the facilitators and barriers encountered during the development of the repository and the lessons learned regarding the reuse of EHR data for surveillance and research purposes.
View Article and Find Full Text PDFPituitary
December 2024
Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Adrenocorticotropin (ACTH)-dependent Cushing's syndrome can arise from a pituitary tumour (Cushing's disease) or an ectopic ACTH-secreting tumour, making precise differentiation essential for effective treatment. Bilateral inferior petrosal sinus sampling (BIPSS) is the gold standard for this differentiation, but false-negative results can limit its accuracy. Adding prolactin (PRL) measurement to BIPSS has been proposed to improve diagnostic precision.
View Article and Find Full Text PDFCancer Genet
December 2024
School of Life Sciences, Shanghai University, Shanghai 200444, China. Electronic address:
CD4 T cells play a pivotal role in the immune system, particularly in adaptive immunity, by orchestrating and enhancing immune responses. CD4 T cell-related immune responses exhibit diverse characteristics in different diseases. This study utilizes gene expression analysis of CD4 T cells to classify and understand complex diseases.
View Article and Find Full Text PDFJ Clin Epidemiol
December 2024
Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA.
Objective: We sought to empirically evaluate whether the width of confidence interval (CI) of the relative risk (RR) and odds ratio (OR) can obviate the need for calculating the optimal information size (OIS) when making GRADE imprecision judgments.
Study Design And Setting: We analyzed a convenience sample of meta-analyses extracted from the Cochrane Database of Systematic Reviews. From each meta-analysis, we calculated OIS based on relative risk reductions (RRR) of 15%-50% and evaluated the ratio of upper to lower 95% CI boundaries of RR (RR CI ratio) and OR (OR CI ratio).
J Am Med Inform Assoc
December 2024
Department of Radiology and Medical Informatics, University of Geneva, 1202 Geneva, Switzerland.
Objectives: Clinical trials (CTs) are essential for improving patient care by evaluating new treatments' safety and efficacy. A key component in CT protocols is the study population defined by the eligibility criteria. This study aims to evaluate the effectiveness of large language models (LLMs) in encoding eligibility criterion information to support CT-protocol design.
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