This study investigates the relationship between the sources of MEG interictal spikes and the distribution of spikes in invasive ECoG in a group of 38 epilepsy patients. An amplitude/surface area measure is defined to quantify ECoG spikes. It is found that all MEG spikes are associated with an ECoG spike that is, according to this measure, among the largest in each patient. For different brain regions considered the inter-hemispheric, tempero-lateral and central regions stand out. However, MEG may only see part of the often complex ECoG spike. In an accompanying simulation study it is shown that MEG as predicted from measured complex ECoG spikes resemble measured MEG and show similar shortcomings with respect to localization.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1109/IEMBS.2009.5333922 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Role of Acetylcholinesterase Enzyme Inhibitor Rivastigmine on Spike-Wave Discharges, Learning-Memory, Anxiety, and TRPV1 Channel Expression in Genetic Absence Epileptic WAG/Rij Rats.
Neurochem Res
January 2025
Department of Physiology, Faculty of Medicine, University of Ondokuz Mayıs, Samsun, Türkiye.
In the present study, the effects of the acetylcholinesterase (AChE) enzyme inhibitor rivastigmine (RIVA) on spike-wave discharges (SWDs), memory impairment, anxiety-like behavior, and the transient receptor potential vanilloid 1 (TRPV1) gene expression were investigated in genetic absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. After tripolar electrodes were implanted on the WAG/Rij rats' skulls, single doses of 0.125, 0.
View Article and Find Full Text PDFAnnotated interictal discharges in intracranial EEG sleep data and related machine learning detection scheme.
Sci Data
December 2024
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
Interictal epileptiform discharges (IEDs) such as spikes and sharp waves represent pathological electrophysiological activities occurring in epilepsy patients between seizures. IEDs occur preferentially during non-rapid eye movement (NREM) sleep and are associated with impaired memory and cognition. Despite growing interest, most studies involving IED detections rely on visual annotations or employ simple amplitude threshold approaches.
View Article and Find Full Text PDFThis study aimed to investigate the role of the nigrostriatal dopaminergic system in the modulation of absence epilepsy. Immunochemical analysis of the rostral pole of the substantia nigra pars compacta (SNpc) was conducted on 13 adult male Wistar Albino rats from Rijswijk rats. The rostral pole of the SNpc included the dorsal and lateral parts.
View Article and Find Full Text PDFTransorbital intraoperative electrocorticography-guided surgical resection for medically refractory developmental epileptic encephalopathy with spike-wave activation in sleep.
Epilepsy Behav Rep
September 2024
The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, the United States of America.
Developmental epileptic encephalopathy with spike-wave activation in sleep (DEE-SWAS) is an epilepsy syndrome of childhood characterized by developmental delay or regression with significant abnormal epileptiform activity during sleep. In some cases, DEE-SWAS with an identified focal lesion is treated with surgical resection. The authors report an unusual case of focal DEE-SWAS that was successfully treated via transorbital resection with intraoperative electrocorticography (iECoG).
View Article and Find Full Text PDFOverlap of spike and ripple propagation onset predicts surgical outcome in epilepsy.
Ann Clin Transl Neurol
October 2024
Neuroscience Research Center, Jane and John Justin Institute for Mind Health, Cook Children's Health Care System, Fort Worth, Texas, USA.
Article Synopsis
- The study investigates the role of spike-ripple onset overlap (SRO) as a potential biomarker for identifying the epileptogenic focus in patients with drug-resistant epilepsy.
- SRO demonstrated higher specificity and precision in predicting successful surgical outcomes compared to other commonly used markers, indicating its clinical significance.
- The findings support the idea that identifying and targeting SRO could lead to better treatment strategies and reduced need for extended monitoring in epilepsy patients.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!