This paper presents the design, mathematical model, fabrication and testing of a novel type of in-vivo stiffness sensor. The proposed sensor can measure both tissue stiffness and contact force. The sensing concept utilizes multiple membranes with varying stiffness and is particularly designed for integration with minimally invasive surgical (MIS) tools. In order to validate the new sensing concept, MEMS capacitive sensors are fabricated using surface micromachining with each fabricated sensor having a 1mm x 1mm active sensor area. Finally, the sensors are tested by touching polymers of different elastic stiffnesses. The results are promising and confirm the capability of the sensor for measuring both force and tissue compliance.
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http://dx.doi.org/10.1109/IEMBS.2009.5332865 | DOI Listing |
Nanoscale
January 2025
National Engineering Research Center for Colloidal Materials, School of Chemistry & Chemical Engineering, Shandong University, Jinan 250100, P. R. China.
The controllable synthesis of monodisperse mesoporous silica microspheres with unique physicochemical properties is becoming increasingly important for a variety of applications such as catalysts, chromatography, drug delivery and sensors. Here, we report a facile microfluidic-assisted sol-gel method for the preparation of silica microspheres with precisely controlled properties such as the size of the microspheres, the surface morphology, porosity and stiffness. All these properties can be manipulated by changing specific synthesis parameters, such as changing the microfluidic channels to tune the size of the microdroplets (tens to hundreds of microns), changing the contents of the precursor solution to manipulate the surface morphology (wrinkled to smooth surface) and changing the gelation/annealing conditions to tune the porosity (surface area up to 1021 m g) and stiffness of the microspheres (elastic modulus tunable from 0.
View Article and Find Full Text PDFMagn Reson Med
January 2025
MRI Research Centre, Physics, University of New Brunswick, Fredericton, New Brunswick, Canada.
Purpose: Magnetic resonance elastography (MRE) provides detailed maps of tissue stiffness, helping to diagnose various health conditions, but requires the use of expensive clinical MRI scanners. Our approach utilizes compact, cost-effective portable MR sensors that offer bulk characterization of material properties in a region of interest close to the surface (within 1-2 cm). This accessible instrument could enable routine monitoring and prevention of diseases not readily evaluated with conventional tools.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Changchun Institute of Optics, Fine Mechanics and Physics (CIOMP), Chinese Academy of Sciences, Changchun 130033, China.
To improve maneuverability, the focus of photoelectric theodolites is on reducing the weight of the primary mirror and enhancing its optical performance. This study uses MOAT and Sobol methods to identify key parameters that affect design. Using the high-sensitivity part as the optimization domain, six optimization results were obtained based on the multi-objective SIMP topology optimization method and synthesized into a compromise optimization structure.
View Article and Find Full Text PDFNat Protoc
January 2025
Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Cell-matrix interactions, mediated by cellular force and matrix remodeling, result in dynamic reciprocity that drives numerous biological processes and disease progression. Currently, there is no available method for directly quantifying cell traction force and matrix remodeling in three-dimensional matrices as a function of time. To address this long-standing need, we developed a high-resolution microfabricated device that enables longitudinal measurement of cell force, matrix stiffness and the application of mechanical stimulation (tension or compression) to cells.
View Article and Find Full Text PDFBiosens Bioelectron
January 2025
School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States; The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, United States; Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA, United States. Electronic address:
Since physiological and pathological events change the mechanical properties of cells, tools that rapidly quantify such changes at the single-cell level can advance the utility of cell mechanics as a label-free biomarker. We demonstrate the capability to probe the population-level elastic modulus and fluidity of MDA-MB-231 cells at a throughput of up to 50 cell/second within a portable microchip. Our sensing scheme adapts a code multiplexing scheme to implement a distributed network of sensors throughout the microchip, thereby compressing all sensing events into a single electrical output.
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