Mechanisms by which whole chromosome instability lead to tumorigenesis have eluded the cancer research field. In this issue of Cancer Cell, Baker et al. show that CIN induced by a defective mitotic checkpoint, under certain genetic and tissue contexts, leads to accelerated loss of heterozygosity of a tumor suppressor gene.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513159 | PMC |
| http://dx.doi.org/10.1016/j.ccr.2009.11.014 | DOI Listing |
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