AI Article Synopsis
- The PI3K pathway plays a crucial role in managing vital cell functions such as survival, growth, and metabolism, making it essential for overall cellular communication.
- Due to frequent mutations in the PI3Kalpha isoform linked to cancer, it has become a significant target for drug development in treating solid tumors.
- Research in structural biology is shedding light on how PI3K flexibility affects mutations, drug resistance, and the selective targeting of these enzymes in various diseases.
Article Abstract
The PI3K pathway is a communication hub coordinating critical cell functions including cell survival, cell growth, proliferation, motility and metabolism. Because PI3Kalpha harbors recurrent somatic mutations resulting in gains of function in human cancers, it has emerged as an important drug target for many types of solid tumors. Various PI3K isoforms are also being evaluated as potential therapeutic targets for inflammation, heart disease, and hematological malignancies. Structural biology is providing insights into the flexibility of the PI3Ks, and providing basis for understanding the effects of mutations, drug resistance and specificity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821964 | PMC |
| http://dx.doi.org/10.1016/j.bbapap.2009.11.020 | DOI Listing |
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