The tri-dimensional (3D) structure determined by NMR of functionally relevant High Activity Binding Peptides (HABPs) of chemically-synthesized malarial proteins, involved in invasion to target cells, is practically identical, at the atomic level, to their corresponding recombinantly produced proteins, determined by X-ray crystallography. Both recombinant proteins as well as these chemically-synthesized HABPs bind to host-cell receptors through channels or troughs formation, stabilized by hydrogen bonding; most of them are located on distant segments to the highly polymorphic, highly antigenic, strain specific amino acid sequences the parasite uses to evade immune pressure. When these immunologically silent conserved HABPs are specifically modified, they become highly immunogenic and capable of inducing protective immune responses, supporting the specifically modified minimal subunit-based, multiepitopic, chemically-synthesized vaccines concept.
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http://dx.doi.org/10.1016/j.pbiomolbio.2009.10.006 | DOI Listing |
Nat Commun
January 2025
Department of Physics, Harvard University, Cambridge, MA, USA.
High-resolution fluorescence imaging of ultracold atoms and molecules is paramount to performing quantum simulation and computation in optical lattices and tweezers. Imaging durations in these experiments typically range from a millisecond to a second, significantly limiting the cycle time. In this work, we present fast, 2.
View Article and Find Full Text PDFInt J Pharm
January 2025
SSPC Research Centre, Department of Chemical Sciences & Chemical Engineering, Bernal Institute, University of Limerick, Limerick V94 T9PX Ireland. Electronic address:
Atomization-based techniques are widely used in pharmaceutical industry for production of fine drug particles due to their versatility and adaptability. Key performance measure of such techniques is their ability to provide control over critical quality attributes (CQAs) of produced drug particles. CQAs of drug particles produced via atomization critically depend on fluid dynamics of sprays; resulting mixing, heat and mass transfer; distribution of supersaturation and subsequent nucleation and growth of particles.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Radiation Engineering Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 11371, Egypt.
In today's digital age, there is an increasing demand for integrated wireless and wired technologies; however, there is a difficulty in achieving secure and reliable communications within buildings and facilities. This paper presents a proposal for maintaining the infrastructure while expanding it to implement communication technologies with high transmission and reception speeds and high levels of data confidentiality to enhance the operational efficiency of organizations. Three main technologies have emerged as promising solutions for this purpose: Wi-Fi, Li-Fi, and BPL.
View Article and Find Full Text PDFPhys Rev Lett
November 2024
Institut für Quantenoptik und Quanteninformation, Österreichische Akademie der Wissenschaften, Technikerstraße 21a, 6020 Innsbruck, Austria.
We present the first successful trapping of single erbium atoms in an array of optical tweezers. Using a single narrow-line optical transition, we achieve deep cooling for direct tweezer loading, pairwise ejection, and continuous imaging without additional recoil suppression techniques. Our tweezer wavelength choice enables us to reach the magic trapping condition by tuning the ellipticity of the trapping light.
View Article and Find Full Text PDFNature
December 2024
Institute of Physics, University of Freiburg, Freiburg, Germany.
Tailored light-matter interactions in the strong coupling regime enable the manipulation and control of quantum systems with up to unit efficiency, with applications ranging from quantum information to photochemistry. Although strong light-matter interactions are readily induced at the valence electron level using long-wavelength radiation, comparable phenomena have been only recently observed with short wavelengths, accessing highly excited multi-electron and inner-shell electron states. However, the quantum control of strong-field processes at short wavelengths has not been possible, so far, because of the lack of pulse-shaping technologies in the extreme ultraviolet (XUV) and X-ray domain.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!