AI Article Synopsis
- - This study looked at how transmissible spongiform encephalopathies (like mad cow disease) can be transmitted between different species by examining prion proteins.
- - Researchers focused on how disease-associated prion proteins (PrPd) affect the normal form of prion proteins in humans, considering three key genetic variants.
- - Results indicated that the shape of PrPd plays a significant role in determining how susceptible different hosts are to these diseases.
Article Abstract
To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044515 | PMC |
| http://dx.doi.org/10.3201/eid1512.090194 | DOI Listing |
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