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Background: Anticoagulant rodenticides (ARs) are a very effective tool to control rodent pest populations. Nevertheless, AR resistance has been documented worldwide. ARs block the cycle of vitamin K, leading to the death of the animal by internal bleeding: mutations in Vkorc1 gene can cause resistance.
View Article and Find Full Text PDFWidespread anticoagulant resistance in house mice (Mus musculus musculus) linked to the Tyr139Phe mutation in the Czech Republic.
Sci Rep
January 2025
Czech Agrifood Research Center, Drnovska 507/73, CZ-16100, Prague 6, Czech Republic.
Despite the widespread use of anticoagulant rodenticides in baits for controlling commensal rodent pests, their application is problematic due to secondary intoxication and increasing resistance. In contrast to studies on Western European house mice (Mus musculus domesticus), few resistance studies have focused on Eastern European house mice (M. musculus musculus), which have a western distribution boundary in the Czech Republic.
View Article and Find Full Text PDFApplication of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy.
Sci Rep
December 2024
Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
Warfarin is the most widely used oral anticoagulant in clinical practice. The cytochrome P450 2C9 (CYP2C9), vitamin K epoxide reductase complex 1 (VKORC1), and cytochrome P450 4F2 (CYP4F2) genotypes are associated with warfarin dose requirements in China. Accurate genotyping is vital for obtaining reliable genotype-guided warfarin dosing information.
View Article and Find Full Text PDFCellular and biochemical approaches to define GGCX carboxylation of vitamin K-dependent proteins.
Methods Enzymol
November 2024
Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine at CWRU, Cleveland, OH, United States.
Article Synopsis
- Gamma-glutamyl carboxylase (GGCX) is crucial for modifying vitamin K-dependent proteins by adding carboxyl groups, which is essential for their functions in blood clotting and bone health.
- Mutations in GGCX can lead to diseases such as vitamin K clotting factor deficiency and pseudoxanthoma elasticum-like diseases, but the mechanisms behind these mutations are not fully understood.
- This chapter discusses biochemical and cellular methods used to study GGCX's function and the impact of its mutations, highlighting the need for a balanced presence of various components and methodologies to fully understand the enzyme's activity.
Clinical, Laboratory, and Molecular Characteristics of Inherited Vitamin K-Dependent Coagulation Factors Deficiency.
Semin Thromb Hemost
November 2024
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.
Vitamin K-dependent coagulation factors deficiency (VKCFD) is a rare autosomal recessive genetic disease characterized by impaired levels of multiple coagulation factors (II, VII, IX, and X) and natural anticoagulants (proteins C and S). VKCFD is part of familial multiple coagulation factor deficiencies, reporting overall 50 affected families thus far. Disease manifestations are quite heterogeneous, bleeding symptoms may vary, and even, although generally mild, some patients may succumb to fatal outcomes.
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