A big challenge for research today is the manipulation of the immune system in order to destroy the neoplastic cells of tumors different origins by using cytokines and other immunostimulants. Interferon-alpha (IFN-alpha) has been used clinically and has been shown to inhibit the proliferation of various cell types in vivo and in vitro. This cytokine has been widely used in the treatment of infectious and chronic degenerative diseases and cancer. In this review, we describe different patents covering the use of cytokines and peptides as therapies for cervical intraepithelial neoplasias and cervical cancer, paying special attention to the use of IFN-alpha.
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Efficacy of Topical Treatment of Low-Risk Cervical Preinvasive Lesions with Glycyrrhizinic Acid.
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Gynaecology Clinic, Riga East Clinical University Hospital, Hipokrata Street 2, LV 1079 Riga, Latvia.
: The study aimed to investigate the efficacy of medication treatment with glycyrrhizinic acid for cervical intraepithelial neoplasia (CIN) 1 lesions. : Women with histologically confirmed CIN 1 in cervical biopsies were included in the prospective study. Participants of the study group used glycyrrhizinic acid spray (Epigen spray) topically 10 days (Epigen 10-day subgroup) or 20 days (Epigen 20-day subgroup) per month for 6 months.
View Article and Find Full Text PDFAgreement Between High-Risk Human Papillomavirus Testing in Paired Self-Collected and Clinician-Collected Samples from Cervical Cancer Screening in Spain.
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Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.
: Implementing self-sampling (SS) in cervical cancer screening requires comparable results to clinician-collected samples (CCS). Agreement measures are essential for evaluating HPV test performance. Previous studies on non-paired samples have reported higher viral cycle threshold (Ct) values in SS compared to CCS, affecting sensitivity for detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2+).
View Article and Find Full Text PDFApplying Results of Extended Genotyping to Management of Positive Cervicovaginal Human Papillomavirus Test Results: Enduring Guidelines.
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Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD.
Objective: The Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee developed recommendations for the use of extended genotyping results in cervical cancer prevention programs.
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Department of Laboratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011.
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Materials And Methods: A retrospective analysis was conducted of the results of cytological screening examinations (Pap test) in Amazonas State from 2013 to 2023. For this purpose, Brazilian public databases Cervical Cancer Information System (SISCOLO) and Cancer Information System (SISCAN) (from The Department of Information and IT of the Unified Health System - DATASUS) were consulted.
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