Introduction: Ultrasound imaging, using either an inline or an external transducer, is a standard method for extracorporeal shockwave lithotripsy (SWL) monitoring. This study investigates whether image distortions caused by the low sound speed of fatty tissue could lead to incorrect stone positioning such that disintegration is affected.
Materials And Methods: To define the accuracy needed for SWL monitoring, the dependency of fragmentation efficiency on the distance between stone center and SWL focus was examined by in vitro model stone tests. In a clinical study, 15 patients with kidney stones were treated with a Dornier Sigma FarSight. This lithotripter was equipped with both an inline and an external transducer. They were operated alternately to check for inconsistencies, which would indicate ultrasound image distortions. In addition, the ultrasound paths from the transducer to the SWL focus were analyzed for error estimation.
Results And Discussion: In the model stone tests, the number of shock waves required for complete fragmentation doubled if the stone was about 7.5 to 10 mm off focus in lateral direction. In the clinical trial, the stone positions obtained from an inline and an external transducer coincided within a 5 mm range of tolerance, but that approach suffered from some practical difficulties, resulting in measurement imprecision. The sound path analysis showed that the lengths through fatty tissue were too short to result in significant image distortion. The body mass index (20-31 kg/m(2)) was representative, except for very obese patients. Additional confirmation of correct stone positioning could be achieved quite easily by looking for pixel movement in the B-mode image or employing Doppler hit/miss monitoring.
Conclusion: Within the study group, no image distortion caused by fatty tissue that could be clinically relevant for SWL was observed.
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http://dx.doi.org/10.1089/end.2009.0158 | DOI Listing |
ACS Appl Mater Interfaces
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College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
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Department of Materials and Environmental Technology, Tallinn University of Technology, Ehitajate tee 5, 19086, Tallinn, Estonia. Electronic address:
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Department of Pharmacology & Toxicology, Cancer Center & Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Oncolytic virotherapy has shown great promise in mediating targeted tumor destruction through tumor-selective replication and induction of anti-tumor immunity; however, obstacles remain for virus candidates to reach the clinic. These include avoiding neutralizing antibodies, preventing stimulation of the adaptive immune response during intravenous administration, and inducing sufficient apoptosis and immune activation so that the body's defense can work to eradicate systemic disease. We have developed a co-formulation of oncolytic viruses (OVs) with Imagent lipid-encapsulated, perfluorocarbon microbubbles (MBs) to protect the OVs from the innate and adaptive immune system.
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Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, China.
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