AI Article Synopsis
Article Abstract
Objective: To report preliminary experience of the protocol of combining Campath 1H induction with low-dose monotherapy of tacrolimus and no steroid in two cases of small bowel transplantation.
Methods: Campath 1H 30 mg was infused during the small bowel transplantation, and the patients were given 1 gram of methylprednisolone followed by the Campath 1H and another gram of methylprednisolone before reperfusion. Tacrolimus was infused just after the reperfusion. The tacrolimus was administered from vein first and then from gut tract, the blood tacrolimus level was controlled at 10 to 15 microg/L within the first 3 months after the operation, and reduced to 5 microg/L thereafter.
Results: The two recipients have survived more than 1 year, one received surgical closure of intestinal graft terminal stoma 13 months after the transplantation. One episode of indeterminate to mild acute rejection was verified by pathology through routine ileoscopical biopsy in each cases, and one episode of mild to moderate acute rejection occurred 8 months after the transplantation, and the patients recovered after low dose or bolus steroid therapy. The peripheral lymphocyte counts and monocyte counts decreased greatly after Campath 1H was given, and recovered very slowly thereafter. No sign of infection and graft versus host disease (GVHD) was found, and the grafted intestine achieved excellent function. The total parenteral nutrition was ceased on the day 21 and 14 after the operation, respectively, and the patients lived on oral intake to maintain nutrition status.
Conclusions: It's showed that the protocol combining Campath 1H induction with low-dose monotherapy of tacrolimus without steroid in small bowel transplantation can control graft rejection effectively without increasing the opportunity of infection, no sign of GVHD is found, and the grafted intestine could achieve excellent function.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Intussusception in children with celiac disease.
J Family Med Prim Care
November 2024
Pediatric Department, Jeddah, Saudi Arabia.
Celiac disease (CD) is a chronic illness. Blood testing for tissue transglutaminase antibodies is the initial screening test for the diagnosis of CD, and upper gastrointestinal endoscopy and duodenal/jejunal biopsy are used to confirm CD. Intussusception (IS) is the process in which a proximal segment of the bowel invaginates through the lumen of a distal segment.
View Article and Find Full Text PDF[Optimization of the culture system for chicken small intestinal organoids].
Sheng Wu Gong Cheng Xue Bao
December 2024
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, Henan, China.
In order to establish a stable in vitro culture platform for chicken small intestine three-dimensional (3D) organoids, in this study, crypt cells were collected from the small intestine of 18-day-old embryos of AA broilers. On the basis of the L-WRN conditioned medium, we optimized the culture conditions of chicken small intestinal organoids by adjusting the proportions of nicotinamide, N-acetylcysteine, LY2157299, CHIR99021, Jagged-1, FGF, and other cytokines to select the medium suitable for the long-term stable growth of the organoids. The optimization results showed that the addition of 1.
View Article and Find Full Text PDFTransition from point A to volume based image guided brachytherapy across a network of centers in India through workshop and mentoring.
Brachytherapy
December 2024
Medical Affairs, Varian Medical Systems, Inc., Palo Alto, CA; Department of Radiation Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA. Electronic address:
Aim: To demonstrate how workshop and mentoring across a network of radiotherapy centers helped in transitioning from point A to volume-based image guided brachytherapy in carcinoma cervix.
Materials And Methods: Based on discussion with different centers across the network, the lapses in cervical cancer treatment were identified and a workshop was designed to change the practice pattern. The main focus of the workshop was to streamline EBRT dose prescription protocols and implement volume based image guided brachytherapy through mentoring and hands on training.
[A Case of Primary Angiosarcoma of the Small Intestine Triggered by Gastrointestinal Bleeding].
Gan To Kagaku Ryoho
December 2024
Digestive Disease Center, Showa University Northern Yokohama Hospital.
An 87-year-old man with complaints of palpitations and digestive bleeding previously visited another hospital. He was referred to our hospital because of anemia. Small bowel endoscopy revealed an elevated lesion with bleeding from the ileum.
View Article and Find Full Text PDFAlleviating effects of dietary formic acid polymer supplementation on lipopolysaccharide-induced inflammatory injury in gut-liver axis of broilers.
Poult Sci
December 2024
Key Laboratory of Efficient Utilization of Non-Grain Feed Resources, College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Panhe Street 7, Tai'an 271017, China. Electronic address:
A close interplay exists between the gut and liver, known as the "gut-liver axis", which plays a vital role in health and disease. This research aimed to explore the effects of dietary formic acid polymer (FAP) addition on inflammatory injury in gut-liver axis of broilers due to lipopolysaccharide (LPS) challenge. Four hundred and fifty 1-day-old male Arbor Acres broilers were assigned to three treatment groups: (1) control (non-challenged, basal diet); (2) LPS (LPS-challenged, basal diet); (3) LPS+FAP (LPS-challenged, basal diet with 1,000 mg/kg FAP).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!