AI Article Synopsis
- The study aimed to investigate how puerarin and its nanoparticles are absorbed in a Caco-2 cell model, focusing on the effects of time and drug concentration.
- Using high-performance liquid chromatography, researchers found that puerarin-PLGA-NP significantly enhances the drug's absorption through mechanisms beyond simple passive diffusion, including better dispersion and interaction with the intestinal lining.
- The findings suggest that while the primary absorption method is passive transfer, the use of nanoparticles (Puerarin-NP) notably improves the drug's uptake in intestinal cells.
Article Abstract
Objective: To study the absorption mechanism of puerarin and its nanoparticles across Caco-2 cell model.
Methods: The Caco-2 monolayer model was used to explore the effect of time and drug concentration on the absorption of puerarin and its nanoparticeles. The drug concentration was determined by high-performance liquid chromatography and the Papp was caculated.
Results: The puerarin-PLGA-NP could significantly improve the absorption of puerarin. Puerarin was not only absorbed simply through passive diffusion, but also had relations with high dispersion of nanoparticles, increase of affinity and interaction with intestinal mucous membrane.
Conclusion: The main mechanism of puerarin and its nanoparticles across Caco-2 monolayer model is passive transference. Puerarin-NP could increase the absorption of the drug in intestinal epithlial.
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