Objective: To determine the suitable regions of Acanthopanax senticosus and provide the basis for its resource census, reservation, wild nature and cultivation.

Methods: The traditional Chinese medicine geographic information system (TCMGIS) was used to select the suitable producing areas.

Results: The ecological environments of 269 counties in 11 province or directly governed city region were suitable for Acanthopanax senticosus. They were located in Xiaoxing'anling, Changbai Mountain, Daxing' anling, Yanshan Mountains, Taihang Mountains and Qinling, among which Heilongjiang accounted for 49.3% and Inner Mongolia reached 22.4%, Jilin reached 16.5%, Liaoning reached 4.3%, the total of Hebei, Beijing, Henan, Shanxi, Sichuan and Gansu was 7.4%.

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