Introduction: Portal vein thrombosis (PVT) was once considered a contraindication for liver transplantation (LTx) because of technical difficulties. Though no longer a contraindication, it remains a risk factor.

Aim: A study of surgical complications following LTx in patients with and without PVT.

Patients And Methods: A retrospective review of 1,171 consecutive patients who underwent LTx between June 1995 and June 2007 was performed, and 78 recipients with PVT (study group) were compared with a stratified random sample of 78 contemporous recipients without PVT (control group) for postoperative complications. Both groups were comparable with respect to age, sex, race, and other confounding variables.

Results: The rate of primary nonfunction (PNF) in the study and control groups was 9.0% and 1.3%, (p = 0.063), while that of retransplantation was 17.9% and 7.7% (p = 0.055), respectively. The mean donor risk index (DRI) among the patients with and without PNF in the study group was 2.58 +/- 0.44 and 2.08 +/- 0.42, respectively (p = 0.014). A significantly higher number of packed red blood cells and fresh frozen plasma transfusions were observed in study group compared to controls (p = 0.012, 0.007, respectively).

Conclusion: A higher rate of PNF was related to the complexity of the surgical procedure and the use of donor livers with a high DRI. Higher rates of PNF eventually led to a higher rate of retransplant. A strategy of offering donor livers with a low DRI might be helpful in decreasing the rate of PNF. Further, a PV interposition graft in difficult cases instead of thrombectomy could lead to a lower rethrombosis rate.

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http://dx.doi.org/10.1007/s11605-009-1111-4DOI Listing

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