Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1373/clinchem.2009.135970 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Molecular Biology of Placental Transport of Calcium to the Human Foetus.
Int J Mol Sci
January 2025
Department of Clinical Biochemistry, University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton SO16 6YD, UK.
From fertilisation to delivery, calcium must be transported into and within the foetoplacental unit for intracellular signalling. This requires very rapid, precisely located Ca transfers. In addition, from around the eighth week of gestation, increasing amounts of calcium must be routed directly from maternal blood to the foetus for bone mineralisation through a flow-through system, which does not impact the intracellular Ca concentration.
View Article and Find Full Text PDFNovel Placental Biomarker Shows Predictive Potential for Spontaneous Preterm Labor.
Am J Perinatol
December 2024
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
Article Synopsis
- The objective of the study was to explore the signaling pathways originating from the placenta that contribute to spontaneous preterm labor, using advanced techniques like single-cell RNA sequencing.
- Researchers found that specific pathways, such as ferroptosis and kisspeptin, were activated in distinct cellular clusters of the placenta from preterm births, with a notable increase in the gene PSG4 related to cellular aging.
- The study concludes that the overexpression of PSG4 could serve as a valuable biomarker for identifying pregnant women at higher risk of preterm delivery, potentially aiding in early interventions.
African origin haplotype protective for Alzheimer's disease in ε4 carriers: exploring potential mechanisms.
bioRxiv
October 2024
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Article Synopsis
- ε4 is the most significant genetic risk factor for Alzheimer's disease (AD), with about half of AD patients having at least one ε4 allele.
- Researchers found that the African-specific A allele of rs10423769 significantly reduces the AD risk associated with ε4 homozygotes by roughly 75%.
- The protective variant is located in a specific region of chromosome 19, demonstrating differences at the structural and DNA methylation levels compared to non-protective variants, and emphasizing the need for diverse ancestry representation in AD studies.
Different Proteomic Profiles Regarding Antihypertensive Therapy in Preeclampsia Pregnant.
Int J Mol Sci
August 2024
Department of Biophysics and Pharmacology, Institute of Biosciences of Botucatu (IBB), São Paulo State University (UNESP), Botucatu 18618-689, SP, Brazil.
Preeclampsia (PE) is a hypertensive pregnancy syndrome associated with target organ damage and increased cardiovascular risks, necessitating antihypertensive therapy. However, approximately 40% of patients are nonresponsive to treatment, which results in worse clinical outcomes. This study aimed to compare circulating proteomic profiles and identify differentially expressed proteins among 10 responsive (R-PE), 10 nonresponsive (NR-PE) patients, and 10 healthy pregnant controls (HP).
View Article and Find Full Text PDFModulation of galectin-9 mediated responses in monocytes and T-cells by pregnancy-specific glycoprotein 1.
J Biol Chem
September 2024
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Electronic address:
Successful pregnancy relies on a coordinated interplay between endocrine, immune, and metabolic processes to sustain fetal growth and development. The orchestration of these processes involves multiple signaling pathways driving cell proliferation, differentiation, angiogenesis, and immune regulation necessary for a healthy pregnancy. Among the molecules supporting placental development and maternal tolerance, the families of pregnancy-specific glycoproteins and galectins are of great interest in reproductive biology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!