AI Article Synopsis
- Ginkgolides A and B increase the susceptibility of recombinant human prion protein (90-231) to proteolysis, indicating a shift towards a non-infective form.
- In the presence of ginkgolides, the prion protein shows greater thermostability compared to conditions without them.
- This suggests that ginkgolides may have neuroprotective effects by altering the structure of prion proteins.
Article Abstract
In the presence of ginkgolides A and B a recombinant human prion protein (90-231) is more susceptible to proteolysis, which is characteristic for the non-infective form of prion proteins and more thermostable than in the absence of ginkgolides. Probably, ginkgolides exert a neuroprotective effect through a rearrangement of the prion structure.
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| http://dx.doi.org/10.2174/092986610790780314 | DOI Listing |
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