Reserpine functions as an anti-stress agent providing relaxation to animals under stressful conditions. An attempt was made to find out functions of reserpine in unstressed albino rats and its role in steroidogenesis. The effects of the drug (25 and 35 microg, im daily for 3-5 days) were observed by recording the changes in body weights, concentration of ascorbate (liver and adrenals) and cholesterol (liver, adrenal and testes) of the animals. A dose of 25 microg reserpine 3-5 days was ineffective as there were no significant changes after the treatment. On the other hand 35 microg reserpine was found to be effective because there was significant increase in body weights, levels of ascorbate and cholesterol in respective tissues after 3-5 days administration. Therefore it is clear that in unstressed animals reserpine is stimulatory for liver but inhibitory for adrenal and testes under high doses.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Scale-Up of Tailor-Made Onsite Enzyme Blend From Cassava Peels for Industrial Bioethanol Production.
ScientificWorldJournal
January 2025
Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Bioethanol production is one of the key alternatives for fossil fuel use due to climate change. The study seeks to upscale tailor-made onsite enzyme blends for the bioconversion of cassava peels to bioethanol in simultaneous saccharification and fermentation (SSF) process using cassava peels-degrading fungi. The starch and cellulose contents of peels were determined.
View Article and Find Full Text PDFLong-Term Opioid Use After Free Flap Breast Reconstruction: Incidence and Associated Factors.
Plast Surg (Oakv)
February 2025
Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Opioid dependence can occur in 6% to 10% of patients undergoing breast reconstruction. With the expansion of interdisciplinary initiatives to decrease opioid use after surgery, an updated look at the incidence of and risk factors for prolonged opioid dependence after free flap breast reconstruction is essential. We retrospectively identified all cases of free flap breast reconstruction completed at our institution from 2017 to 2020.
View Article and Find Full Text PDFReadmissions and Mortality After "Before Medically Advised" Hospital Discharges Among Medicare Beneficiaries with Opioid Use Disorder.
J Gen Intern Med
January 2025
Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI, USA.
Background: "Before medically advised" (BMA) discharges are rising among hospitalized people with opioid use disorder (OUD) and associated with worse outcomes. However, little is known about BMA discharge among the growing share of U.S.
View Article and Find Full Text PDFNeonatal unit admission and offspring mental health trajectories across childhood and adolescence: a nationally representative UK cohort study.
BMJ Paediatr Open
January 2025
Division of Psychiatry, University College London, London, UK
Objective: To investigate the associations between neonatal unit admission (NNU) and subsequent emotional and behavioural difficulties during childhood and adolescence.
Design: Longitudinal general population cohort study.
Setting: The Millennium Cohort Study: nationally representative UK-based cohort.
An open-label, phase IB/II study of abemaciclib with paclitaxel for tumors with CDK4/6 pathway genomic alterations.
ESMO Open
January 2025
Department of Internal Medicine, Division of Medical Oncology, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:
Background: Disruption of cyclin D-dependent kinases (CDKs), particularly CDK4/6, drives cancer cell proliferation via abnormal protein phosphorylation. This open-label, single-arm, phase Ib/II trial evaluated the efficacy of the CDK4/6 inhibitor, abemaciclib, combined with paclitaxel against CDK4/6-activated tumors.
Patients And Methods: Patients with locally advanced or metastatic solid tumors with CDK4/6 pathway aberrations were included.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!